Integrative multiomics analysis of neointima proliferation in human saphenous vein: implications for bypass graft disease.

Introduction: Human saphenous veins (SV) are widely used as grafts in coronary artery bypass (CABG) surgery but often fail due to neointima proliferation (NP). NP involves complex interplay between vascular smooth muscle cells (VSMC) and fibroblasts. Little is known, however, regarding the transcriptomic and proteomic dynamics of NP.

Aortic Dissection as a Cause of Pulsus Bisferiens: A Case Report and Review.

We present a case of a 62-year-old woman who developed an aortic dissection after aortic valve replacement for aortic stenosis and supracoronary replacement of the ascending aorta for aneurysmal dilation. Dynamic compression of the distal aorta by the dissection flap was identified with the detection of abnormal continuous wave Doppler signals heard while performing ankle-brachial indices. Duplex ultrasound (US) and Doppler spectral waveforms confirmed dynamic compression of the distal aorta with each cardiac cycle.

The use of rigid sternal fixation for complex poststernotomy wounds and a military-unique fracture at an Army medical center.

Sternal wound complications after sternotomy carry significant morbidity and mortality rates. Sternal fractures attributable to blunt trauma may cause incapacitating pain or may be plagued by symptoms resulting from chronic nonunion. A sternal fixation system has been developed and used successfully for the management of poststernotomy complications, as well as for symptomatic fractures and fracture nonunion.

Surgical repair of a chronic traumatic sternal fracture.

Chronic sternal fracture nonunion is usually reported after median sternotomy, but rarely after blunt chest trauma. Most traumatic fractures of the sternum are managed nonoperatively if they are asymptomatic and nondisplaced. Acute surgical therapy is indicated for debilitating chest pain usually associated with fracture displacement.