Publications by authors named "Dominic Ouma"

Background: Maternal immunization is a key strategy for reducing morbidity and mortality associated with infectious diseases in mothers and their newborns. Recent developments in the science and safety of maternal vaccinations have made possible development of new maternal vaccines ready for introduction in low- and middle-income countries. Decisions at the policy level remain the entry point for maternal immunization programs.

View Article and Find Full Text PDF

Maternal vaccination coverage remains suboptimal globally and is lowest in low- and middle-income countries. Attitudes toward maternal vaccines have been characterized in middle-high income settings, however data from African countries are limited. We assessed drivers and barriers of vaccine acceptance among pregnant women in Kenya.

View Article and Find Full Text PDF

Background: Pregnant women and newborns are at high risk for infectious diseases. Altered immunity status during pregnancy and challenges fully vaccinating newborns contribute to this medical reality. Maternal immunization is a strategy to protect pregnant women and their newborns.

View Article and Find Full Text PDF
Article Synopsis
  • Kenya implemented the 10-valent pneumococcal conjugate vaccine (PCV10) for children under 1 year in 2011, along with catch-up vaccination for those aged 1-4 in certain areas, and a study examined the impact on pneumococcal carriage in both children and adults from 2009 to 2013.
  • Surveys revealed significant reductions in PCV10-type carriage among children under 5 years and adults, with notable drops in carriage rates for both HIV-positive and HIV-negative adults, suggesting the vaccine's effectiveness.
  • Despite the decline in PCV10-type carriage, the prevalence of penicillin nonsusceptible pneumococci (
View Article and Find Full Text PDF

With the accelerated introduction of new vaccines in low-income settings, understanding immunization program performance is critical. We sought to improve immunization history acquisition from Ministry of Health vaccination cards during a vaccine impact study of 10-valent pneumococcal conjugate vaccine on pneumococcal carriage among young children in Kenya in 2012 and 2013. We captured immunization history in a low proportion of study participants in 2012 using vaccination cards.

View Article and Find Full Text PDF

There is a theoretical risk of adverse events following immunization with a preservative-free, 2-dose vial formulation of 10-valent-pneumococcal conjugate vaccine (PCV10). We set out to measure this risk. Four population-based surveillance sites in Kenya (total annual birth cohort of 11,500 infants) were used to conduct a 2-year post-introduction vaccine safety study of PCV10.

View Article and Find Full Text PDF