Publications by authors named "Dominic Lichtscheidl"
Article Synopsis
- - During pregnancy and lactation, mammals experience significant changes in their intestinal epithelium, leading to an increase in intestinal surface area through the expansion of villi.
- - The RANK-RANKL molecular pathway is crucial for this process, protecting gut cells from death and promoting intestinal stem cell activity, which results in villous elongation.
- - Mice lacking RANK in their intestinal epithelium have offspring that are heavier and more prone to glucose intolerance, highlighting the importance of RANK-RANKL in both immediate and long-term health outcomes for offspring.
The increased incidence of allergies and asthma has sparked interest in IgE, the central player in the allergic response. Interaction with its high-affinity receptor FcεRI leads to sensitization and allergen presentation, extracellular membrane-proximal domain in membrane IgE can act as an antigen receptor on B cells, and the interaction with low-affinity IgE receptor CD23 additionally influences its homeostatic range. Therapeutic anti-IgE antibodies act by the inhibition of IgE functions by interfering with its receptor binding or by the obliteration of IgE-B cells, causing a reduction of serum IgE levels.
View Article and Find Full Text PDF