3D Printability Assessment of Poly(octamethylene maleate (anhydride) citrate) and Poly(ethylene glycol) Diacrylate Copolymers for Biomedical Applications.

Herein, we present the first example of 3D printing with poly(octamethylene maleate (anhydride) citrate) (POMaC), a bio-adhesive material which has shown particular promise for implantable biomedical devices. The current methods to fabricate such devices made from POMaC are hindered by the imposed constraints of designing complex molds. We demonstrate the feasibility of exploiting additive manufacturing to 3D print structural functional materials consisting of POMaC.

Decoupling manufacturing from application in additive manufactured antimicrobial materials.

3D printable materials based on polymeric ionic liquids (PILs) capable of controlling the synthesis and stabilisation of silver nanoparticles (AgNPs) and their synergistic antimicrobial activity are reported. The interaction of the ionic liquid moieties with the silver precursor enabled the controlled in situ formation and stabilisation of AgNPs via extended UV photoreduction after the printing process, thus demonstrating an effective decoupling of the device manufacturing from the on-demand generation of nanomaterials, which avoids the potential aging of the nanomaterials through oxidation. The printed devices showed a multi-functional and tuneable microbicidal activity against Gram positive (B.

Induced neural stem cell differentiation on a drawn fiber scaffold-toward peripheral nerve regeneration.

To achieve regeneration of long sections of damaged nerves, restoration methods such as direct suturing or autologous grafting can be inefficient. Solutions involving biohybrid implants, where neural stem cells are grown in vitro on an active support before implantation, have attracted attention. Using such an approach, combined with recent advancements in microfabrication technology, the chemical and physical environment of cells can be tailored in order to control their behaviors.

3D-Printable Photochromic Molecular Materials for Reversible Information Storage.

The formulation of advanced molecular materials with bespoke polymeric ionic-liquid matrices that stabilize and solubilize hybrid organic-inorganic polyoxometalates and allow their processing by additive manufacturing, is effectively demonstrated. The unique photo and redox properties of nanostructured polyoxometalates are translated across the scales (from molecular design to functional materials) to yield macroscopic functional devices with reversible photochromism. These properties open a range of potential applications including reversible information storage based on controlled topological and temporal reduction/oxidation of pre-formed printed devices.

Shining a light on the photo-sensitisation of organic-inorganic hybrid polyoxometalates.

Finding new ways of using visible light (or, more specifically, solar irradiation) to drive commercially significant and/or challenging chemical processes is an ongoing research goal. Polyoxometalates (POMs) are discrete, metal-oxide clusters which are cheap, robust and easily synthesised but can also act as versatile molecular building blocks, allowing for astonishing variety in their structures and properties. In particular, the rich redox chemistry and inherent photo-activity of POMs makes them attractive for use in a variety of photochemical applications, however POMs characteristically only absorb strongly in the UV region.

Surface-based molecular self-assembly: Langmuir-Blodgett films of amphiphilic Ln(III) complexes.

The unique photophysical properties of the Ln(III) series has led to significant research efforts being directed towards their application in sensors. However, for "real-life" applications, these sensors should ideally be immobilised onto surfaces without loss of function. The Langmuir-Blodgett (LB) technique offers a promising method in which to achieve such immobilisation.

Gas sensing using porous materials for automotive applications.

Improvements in the efficiency of combustion within a vehicle can lead to reductions in the emission of harmful pollutants and increased fuel efficiency. Gas sensors have a role to play in this process, since they can provide real time feedback to vehicular fuel and emissions management systems as well as reducing the discrepancy between emissions observed in factory tests and 'real world' scenarios. In this review we survey the current state-of-the-art in using porous materials for sensing the gases relevant to automotive emissions.

Monolayer detection of ion binding at a crown ether-functionalised supramolecular surface via an integrated optical Bragg grating.

There have been significant recent developments in the field of integrated optical Bragg grating sensors for use in the biological domain, where changes in the thickness of a surface layer upon specific binding of biological targets allows quantitative detection. However in the chemical domain less work has been reported. We present here an integrated optical Bragg grating sensor, capable of evanescently detecting small changes in refractive index down to 10(-6) RIU at infrared wavelengths, within a microfluidic system.

An investigation into dispersion upon switching between solvents within a microfluidic system using a chemically resistant integrated optical refractive index sensor.

A planar Bragg grating device has been developed that is capable of detecting changes in the refractive index of a wide range of fluids including solvents, acids and bases. The integration of this high precision refractive index sensor within a chemically resistant microfluidic flow system has enabled the investigation of diverse fluid interactions. By cycling between different solvents, both miscible and immiscible, within the microfluidic system it is shown that the previous solvent determines the nature of the refractive index profile across the transition in composition.