Publications by authors named "Dominic Ch Ng"
Article Synopsis
- Mitophagy, the process that removes damaged mitochondria, needs to be tightly controlled to keep cells healthy, with the SCF ubiquitin ligase complex playing a key role by degrading mitophagy receptors BNIP3 and NIX.
- Mutations in the FBXL4 gene can lead to mitochondrial diseases due to increased mitophagy, showing that proper regulation is crucial.
- The phosphatase PPTC7 is essential for linking BNIP3 and NIX to FBXL4 for their degradation, and it helps to prevent excessive mitophagy by responding adaptively to changes in cell conditions.
Background: TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 expression and formation of C-terminal TDP-43 fragmentation and accumulation in the cytoplasm. Recent studies have shown that TDP-43 can accumulate in RNA stress granules (SGs) in response to cell stresses and this could be associated with subsequent formation of TDP-43 ubiquinated protein aggregates. However, the initial mechanisms controlling endogenous TDP-43 accumulation in SGs during chronic disease are not understood.
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