Publications by authors named "Dominguez-Duran E"
Life after benign paroxysmal positional vertigo: one-year analysis of recurrence, headaches, neck pain, falls, and functional vestibular symptoms.
Eur Arch Otorhinolaryngol
January 2025
Article Synopsis
- Benign paroxysmal positional vertigo (BPPV) causes recurring episodes of vertigo, and despite initial symptom resolution, many patients experience relapses and other complications such as migraines, neck pain, and falls after discharge.
- This study observed 124 patients with BPPV and found that 70.97% of them reported new symptoms post-treatment, with prior neck pain, headaches, and migraines being significant predictors for future issues.
- Key findings highlight that low vitamin D levels may increase recurrence risk, and the relationship between anxiety and persistent postural-perceptual dizziness (PPPD) suggests that BPPV is often accompanied by lingering symptoms despite the absence of nystagmus.
Background: Meniere disease (MD), an inner ear disorder influenced by genetic and environmental factors, potentially leads to chronic inflammation. This study evaluates whether inflammation in MD patients is driven by allergy or autoinflammation.
Methods: 2-year longitudinal study.
Article Synopsis
- Migraines (MI) are a common brain problem affecting about 20% of people worldwide, and some people with migraines also have balance issues, which is called vestibular migraine (VM).
- Meniere's disease (MD) is another condition that affects the inner ear and can cause spinning sensations, ringing in the ears, and hearing loss, which sometimes overlaps with vestibular migraine symptoms.
- A study compared blood samples from people with migraines, vestibular migraines, Meniere's disease, and healthy individuals, finding that migraines and vestibular migraines have similar immune responses, while Meniere's disease shows different immune reactions and can be divided into two types based on activity.
Objectives: Hearing recovery following idiopathic sudden sensorineural hearing loss (ISSNHL) is influenced by various prognostic factors, and the presence of acute vestibular syndrome (AVS) may adversely impact auditory outcomes. Evaluating vestibular function in SSNHL patients could offer insights into predicting hearing recovery. This systematic review aims to assess whether the presence of AVS exacerbates the audiological prognosis of ISSNHL.
View Article and Find Full Text PDFIntroduction: Recently, end-point nystagmus, traditionally observed in an upright position, has been identified in the Dix-Hallpike position among healthy subjects, suggesting a physiological origin.However, its characteristics in individuals with vestibular hypofunction remain unexplored.
Objective: To elucidate the impact of vestibular hypofunction on the characteristics of positional end-point nystagmus.
Article Synopsis
- * A study analyzed the RNA of 45 MD patients and 15 healthy individuals, identifying differentially expressed genes that suggest a connection to the immune response in MD.
- * Patients were categorized based on their IL-1β levels, revealing a proinflammatory subgroup with increased IL-6 and certain immune cells, indicating a potential target for future treatments.
Background: Some individuals present positional end-point nystagmus when the Dix-Hallpike tests are performed on them if they unintentionally look towards the examined ear.
Objective: To describe the prevalence and the characteristics of end-point nystagmus during positional testing in healthy subjects.
Methods: Sixty healthy subjects were included.
Paraneoplastic acute vestibular syndrome: What, when and how.
Acta Otorrinolaringol Esp (Engl Ed)
February 2022
Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition.
Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out.
Paraneoplastic acute vestibular syndrome: what, when and how.
Acta Otorrinolaringol Esp (Engl Ed)
March 2021
Introduction: Patients with episodic vestibular syndrome (EVS) whose symptoms resemble those of vestibular migraine (VM) but who do not meet the criteria for it are common.
Objective: To describe those patients suffering from EVS in whom defined etiologies have been ruled out in order to determine if their symptoms can be linked to VM.
Material And Methods: Prospective multicenter study.
Identifying Training, Diagnostic and Therapeutic Needs From a Comparison in the Distribution of Vestibular Disorders in Primary Care and in a Neurotology Unit.
Front Neurol
November 2020
Several epidemiological studies in Neurotology have been previously carried out in the general population. This approach is useful for learning about the most common disorders in clinical population, but it may fail when one is trying to help professionals to guide their training, to optimize their resources and to decide on the highest-priority research objectives. To identify which of the neurotological diseases are most common in two different populations, those who attended a consultation in the Neurotology Unit of a tertiary level hospital and those who did so in Primary Care in order to infer which of them requires more attention in each context and their specific needs.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the connection between balance disorders (BDs), like vertigo, and the risk of strokes (acute cerebrovascular accidents, ACAs), highlighting that existing research has limitations.
- The research involved tracking nearly 8,000 participants over two years to analyze how various cardiovascular risk factors (CVRFs) relate to BDs and ACAs, using both univariate and multivariate analysis methods.
- Findings suggest that while BDs are associated with a higher risk of ACAs, they likely act as confounding factors linked to other CVRFs, serving as indicators for identifying individuals at increased risk for strokes.
Epidemiology of balance disorders in primary care.
Acta Otorrinolaringol Esp (Engl Ed)
October 2021
Article Synopsis
- * A total of 7,896 patients visiting primary care for vertigo, imbalance, or dizziness were analyzed over one year, revealing an annual incidence of BD of 2.2%, with the majority diagnosed and treated within primary care settings.
- * Key findings showed that positional vertigo was the most common diagnosis, followed by vestibular migraines, central nervous system ischemia, and medication side effects, indicating a need for better training in these areas for primary care physicians.
Introduction: Vestibular migraine (VM) consists of recurrent episodes of vestibular symptoms that are accompanied by migraine in at least 50% of the episodes. The criteria of the Bárány Society include two diagnostic categories: "actual" vestibular migraine and probable vestibular migraine. There is a wide range of drugs that can be prescribed for the prophylactic treatment of VM, but recommendations for the selection of the most appropriate drug are currently lacking.
View Article and Find Full Text PDFIncidence of unilateral and bilateral benign paroxysmal positional vertigo when the left and right Dix-Hallpike manoeuvres are positive: a model based on the sense of torsional nystagmus.
Acta Otorhinolaryngol Ital
April 2020
Background: Probable benign paroxysmal positional vertigo, spontaneously resolved (pBPPVsr), is a variant of benign paroxysmal positional vertigo (BPPV) in which there is no observable nystagmus and no vertigo with any positional maneuver.
Objectives: To calculate the incidence pBPPVsr, compare the characteristics of the patients with pBPPVsr and BPPV not spontaneously resolved and describe the spontaneous resolution in the natural course of BPPV.
Methods: Multicenter prospective descriptive study.
Article Synopsis
- - The study aimed to assess how well a group of ten otorhinolaryngologists agreed on prophylactic treatments for vestibular migraine (VM) and whether an assisted algorithm could help improve their decision-making process.
- - Initial agreement among the otolaryngologists was rated as "fair" (Fleiss' κ = .302), but after using the algorithm as an additional evaluator, the agreement improved significantly (Fleiss' κ = .711).
- - The algorithm's suggested treatments aligned closely with the otolaryngologists' choices, leading to enhanced consensus and indicating its potential utility in guiding treatment decisions.
Clinical use of 4-aminopyridine in patients with downbeat nystagmus.
Acta Otorrinolaringol Esp (Engl Ed)
October 2020
Article Synopsis
- - The study aimed to evaluate the effectiveness of 10 mg of sustained-release fampridine (4-AP-SR) in treating downbeat nystagmus in patients.
- - Three patients were treated, but none reported significant changes in their symptoms, and no improvements were detected in their clinical assessments.
- - The findings did not support the efficacy of 4-AP-SR, with potential reasons for contradictions in previous studies being the small sample size and differences in the patient cases or measurement methods.
Introduction: Subjective benign paroxysmal positional vertigo is a form of benign paroxysmal positional vertigo in which during the diagnostic positional maneuvers patients only present vertigo symptoms with no nystagmus.
Objective: To study the characteristics of subjects with subjective benign paroxysmal positional vertigo.
Methods: Prospective multicenter case-control study.
Objectives: To compare the outcome of the Epley maneuver (EM) in benign paroxysmal positional vertigo of the posterior canal (CSP-BPPV) depending on the definition used for recovery.
Design: Multicenter observational prospective study.
Setting: Otoneurology Units of 5 tertiary reference hospitals.
Purpose: To calculate the incidence of subsequent acute cerebrovascular syndrome in emergency department patients with vertigo or dizziness symptoms and to determine predictors of subsequent acute cerebrovascular syndrome in these patients.
Methods: Descriptive and retrospective hospital based-population study among emergency department patients with vertigo or dizziness symptoms in 1 year. One year follow-up since the medical visit was performed.
Analysis of risk factors influencing the outcome of the Epley maneuver.
Eur Arch Otorhinolaryngol
October 2017
Benign paroxysmal positional vertigo (BPPV) is the most frequent type of vertigo. The treatment of canalithiasis of the posterior semicircular canal consists in performing a particle-repositioning maneuver, such as the Epley maneuver (EM). However, the EM is not effective in all cases.
View Article and Find Full Text PDFObjective: The objective was to find a way to estimate the value of inter-ear difference (IED) through monothermal caloric screening testing (MCST) that can be used at any laboratory, controlling and minimising the resulting error.
Methods: We retrospectively included in this study 2304 patients from our department to whom a videonystagmography with caloric testing was performed between 2003 and 2011. The IED was calculated in 3 different ways: Using the values of the 4 caloric stimulations (bithermal form) and using only the 2 same-temperature values (warm monothermal and cool monothermal forms).