Cutaneous biomarkers of therapeutic efficacy in early treatment of hereditary ATTR amyloid polyneuropathy with tafamidis.

Background: ATTR (ATTRv) amyloidosis neuropathy is characterized by progressive sensorimotor and autonomic nerve degeneration secondary to amyloid deposition caused by a misfolded transthyretin protein (TTR). Small nerve fiber neuropathy is an early clinical manifestation of this disease resulting from the dysfunction of the Aδ and C small nerve fibers. Tafamidis, a selective TTR stabilizer, has proven its efficacy in the earlier stages of hATTR.

Latent profiles of problem behavior within learning, peer, and teacher contexts: identifying subgroups of children at academic risk across the preschool year.

Employing a developmental and ecological model, the study identified initial levels and rates of change in academic skills for subgroups of preschool children exhibiting problem behavior within routine classroom situations. Six distinct latent profile types of emotional and behavioral adjustment were identified for a cohort of low-income children early in the preschool year (N=4417). Profile types provided a descriptive picture of patterns of classroom externalizing, internalizing, and situational adjustment problems common to subgroups of children early in the preschool year.

The role of context in preschool learning: a multilevel examination of the contribution of context-specific problem behaviors and classroom process quality to low-income children's approaches to learning.

Research suggests that promoting adaptive approaches to learning early in childhood may help close the gap between advantaged and disadvantaged children. Recent research has identified specific child-level and classroom-level variables that are significantly associated with preschoolers' approaches to learning. However, further research is needed to understand the interactive effects of these variables and determine whether classroom-level variables buffer the detrimental effects of child-level risk variables.

6a,7-Dehydro-N-formylnornantenine and other constituents from Aristolochia brevipes.

From the non-coloured fraction of rhizomes of Aristolochia brevipes (Aristolochiaceae) the new aporphine alkaloid 6a,7-dehydro- N-formylnornantenine was isolated besides N-formylnornantenine, cadalene, and 4-hydroxy-4,7-dimethyl-1-tetralone.

Isolation and identification of xochitloldione and isoxochitlolone from Cnidosculus urens.

Major components of MeOH extracts from the plant roots of Cnidosculus urens purified by cc and tlc and crystallization were lupeol acetate and the previously unreported compounds isoxochitlolone [1] and xochitloldione [2], which were identified through mass, ir, nmr, and uv spectroscopy and X-ray crystallography. In preliminary testing, isoxochitlolone has been found to be active against Escherichia coli and Staphylococcus aureus.

Kukulkanins A and B, new chalcones from Mimosa tenuefolia.

Two new methoxychalcones, kukulkanins A (2',4'-dihydroxy-3',4-dimethoxychalcone) and B (2',4',4-trihydroxy-3'-methoxychalcone), were isolated by flash chromatography of extracts of small branches of Mimosa tenuefolia. The compounds were identified using ir, nmr, uv, and mass spectroscopy, and their structures were confirmed by X-ray crystallography.

Citlalitrione, a new diterpene from Jatropha dioica var. sessiliflora.

Solvent partitioning and column chromatography of MeOH root extracts of Jatropha dioica yielded four pure compounds, beta-sitosterol, jatropholone B, a previously unknown diterpene epoxytrione given the trivial name citlalitrione, and riolozatrione. Structures were determined using physical and spectral techniques and X-ray crystallography.

Further eudesmane derivatives from verbesina species.

The aerial parts of VERBESINA PERSICIFOLIA DC afforded a new eudesmane derivative in addition to known compounds. The roots of V. SUBCORDATA gave also new eudesmane cinnamates in addition to several known ones as well as a 5alpha-hydroxybicyclogermacra-1 (10) E, 4 (15)-diene.

Screening of medicinal plants used by Huastec Mayans of northeastern Mexico.

As part of a research effort to assess the adaptive value of Huastec medicine, a preliminary screening of a sample of the Huastec pharmacopoeia has been carried out. Results from the screening of 56 species are reported here together with information about Huastec use and knowledge of medicinal plants.