Publications by authors named "Domenico Sgambati"
Article Synopsis
- MucR is a transcriptional regulator found in Brucella species that influences gene expression related to virulence by binding to AT-rich DNA regions.
- MucR is part of the Ros/MucR family in α-proteobacteria and shares functional similarities with H-NS proteins, although they lack sequence homology.
- This study uses cryo-EM and other methods to reveal that MucR and its homolog Ml5 form a unique circular structure that can condense DNA, linking nucleoid structure to transcription regulation.
Proteins of the MucR/Ros family play a crucial role in bacterial infection or symbiosis with eukaryotic hosts. MucR from plays a regulatory role in establishing symbiosis with the host plant, both dependent and independent of Quorum Sensing. Here, we report the first characterization of MucR isolated from by mass spectrometry and demonstrate that this protein forms higher-order oligomers in its native condition of expression by SEC-MALS.
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