Publications by authors named "Domenico Quaranta"
Background/aims: An endothelial dysfunction has been described in autosomal dominant polycystic kidney disease (ADPKD) before the development of hypertension and renal impairment. The aim of this work was to verify the existence of a microvascular reactivity in the early stages of ADPKD.
Methods: Fifteen ADPKD normotensive patients with normal renal function underwent laser Doppler examination of the cutaneous microcirculation in basal conditions and after the warm test, as well as evaluation of plasma concentrations of some endothelial activation parameters [total cholesterol and fractions, fibrinogen, von Willebrand factor, Lp(a)].
Article Synopsis
- Clostridiopeptidase A, or collagenase 1, is an enzyme that helps break down collagen and is used in treatments for skin wounds and ulcers.
- Patients using Noruxol ointment, which contains this enzyme, developed periulcerative eczema, prompting further allergy testing.
- Patch testing revealed that most patients had questionable reactions to the ointment, but all reacted positively to clostridiopeptidase A, indicating its potential to cause sensitization in certain individuals.