Publications by authors named "Domenico Migliorini"
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Synopsis of recent research by authors named "Domenico Migliorini"
Domenico Migliorini's research primarily focuses on the regulation of the p53 tumor suppressor pathway, with significant emphasis on the roles of Mdm2 and Mdmx, two key proteins that negatively regulate p53's activity in cancer.
His studies have investigated the molecular mechanisms behind p53 regulation, highlighting how aberrations in these pathways contribute to tumorigenesis, including findings that Mdmx amplification can directly promote tumor formation.
Additionally, Migliorini has explored the roles of β-catenin in embryonic stem cell self-renewal and its implications for developmental biology, focusing on the complex interaction between its functions as a transactivator and its role in cell adhesion.
