The Role of Regional Disease and Patterns of Treatment Failure in Primary Sinonasal Malignancies.

Background: The question how to treat the clinically negative neck in sinonasal malignancies is controversial.

Objectives: To investigate patterns of treatment failure and to assess outcome measures in patients with primary sinonasal malignancies.

Methods: Retrospective cohort study of patients treated for primary malignant sinonasal malignancies.

Impact of the new TNM Staging System (8th edition) on oral tongue cancers.

Aim Of The Study: For tumours of the oral tongue, the most recent 8th edition of the AJCC/UICC staging system has introduced depth of infiltration (DOI) as a novel parameter. With this study we wanted to investigate its impact regarding this risk stratification compared with the preceding 7th edition.

Methods: Between 2008 and 2017, 161 patients of two tertiary referral centres in Switzerland (Kantonsspital St.

Preoperative assessment of CD44-mediated depth of invasion as predictor of occult metastases in early oral squamous cell carcinoma.

Background: Epithelial-mesenchymal transition and cancer stem-like cells (CSC) have been linked to increased metastatic potential. We evaluated the prognostic impact of CD44, a CSC biomarker, on depth of invasion (DOI) and outcome in oral squamous cell carcinoma (OSCC).

Methods: Using a multivariable logistic regression model, we evaluated in early OSCCs the relationship between CD44 expression at the invasive tumor front, DOI, sentinel lymph node biopsy, extension of nodal involvement, and survival.

Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients.

Importance: Squamous cell carcinoma (SCC) is the most frequent malignant neoplasm found in solid organ transplant recipients and is associated with a more aggressive disease course and higher risk of metastasis and death than in the general population.

Objectives: To report the clinicopathologic features of and identify factors associated with aggressive SCC in solid organ transplant recipients.

Methods: This retrospective multicentric case series included 51 patients who underwent solid organ transplantation and were found to have aggressive SCC, defined by nodal or distant metastasis or death by local progression of primary SCC.

Maximum Standardized Uptake Value (SUV) of Primary Tumor Predicts Occult Neck Metastasis in Oral Cancer.

The aim of this study was to investigate the predictability of occult lymph node metastasis using maximum standardized uptake value (SUV) in the primary tumor on pre-treatment 18-fluorodeoxyglucose positron emission tomography FDG-PET in oral squamous cell carcinoma (OSCC) patients who were clinically node negative (cN0) before surgery. A retrospective analysis of all patients treated at the University Hospital Zurich from 2007 to 2016 for OSCC with available pre-therapeutic FDG-PET was performed. We assessed the correlation of SUV of the primary tumors with the presence of occult nodal disease in the neck dissection specimen (pN+).

Perineural Invasion in Squamous Cell Carcinoma of the Oral Cavity: Histology, Tumor Stage, and Outcome.

Objectives/hypothesis: To analyze the impact of different types of perineural invasion (PNI) in squamous cell carcinoma (SCC) of the oral cavity on overall survival and recurrence rate, with a special focus on histologic subtypes and tumor stage.

Study Design: Retrospective case-control study with clinicopathological analysis.

Methods: Seventeen patients who received primary surgical treatment for SCC of the oral cavity with PNI were matched to a control group.