Endocrown: A Minimally Invasive Alternative to Conventional Fixed Prosthesis.

Endodontically treated teeth with compromised coronal tooth structure often require core build-ups with the support of radicular posts. In certain cases, the traditional post and core approach may not be possible due to various anatomical and clinical contraindications. Such cases require more meticulous planning and alternative treatment approaches for successful outcomes.

Differential gene expression profile in treated human gingival keratinocytes and their role in the development of HNSCC.

Background: Periodontitis is considered to be one of the major risk factors associated with cancers of the oral cavity. Periodontogenic pathogens such as and are the important pathogens associated with periodontitis. Chronic exposure to bacterial components induces changes in the nearby cells.

Development and Validation of a Yoga-Based Intervention for Speech Dysfunction and Speech Difficulties Among Patients With Parkinson's Disease.

Introduction Parkinson's disease (PD) is primarily thought to be brought on by the death of dopaminergic neurons in the substantia nigra pars compacta of the basal ganglia. Communication difficulties are a common symptom of PD, affecting both motor speech and language systems. These challenges significantly impact the quality of life by reducing participation in communication, leading to social withdrawal, and increasing the risk of social isolation and stigma among individuals with PD.

A Successful Conservative Management of Twin Gestation of Complete Molar Gestation and Co-Existing Normal Fetus: A Case Report.

Twin pregnancies consisting of one normal fetus and one complete mole are very rare. The main concerning risks associated with the continuation of such pregnancy are hyperthyroidism, theca lutein cysts, preeclampsia, and the development of GTD (gestational trophoblastic disease) spectrum (neoplasia) in the mother, which is due to high human chorionic gonadotropin (HCG) values, and intrauterine death and prematurity in the coexistent normal fetus. We report the successful outcome of conservative management in a healthy mother and baby.

A COMPREHENSIVE REVIEW ON EARLY DETECTION OF DRUSEN PATTERNS IN AGE-RELATED MACULAR DEGENERATION USING DEEP LEARNING MODELS.

Age-related Macular Degeneration (AMD) is a leading cause of visual impairment and blindness that affects the eye from the age of fifty-five and older. It impacts on the retina, the light-sensitive layer of the eye. In early AMD, yellowish deposits called drusen, form under the retina, which could result in distortion and gradual blurring of vision.

Assessment of Self-Medication Practices and Knowledge Among Medical Students in Chengalpattu District: A Cross-Sectional Study.

Introduction: The practice of self-medication is wherein individuals initiate the use of medications without consulting a healthcare professional. College life is a period marked by academic, social, and personal changes. Due to their greater freedom and the pressure of academic success, students face various health issues.

Impact of cartoon-animated video, caregiver-supervised training, and pamphlet on plaque control, oral hygiene status, and oral hygiene knowledge, attitude, and practices in orphaned adolescents: A randomized controlled trial.

Aim: To evaluate the effectiveness of cartoon animated video, caregiver-supervised training, and pamphlet-based oral health education on plaque control, oral hygiene status, and oral health knowledge, attitude, and practice (KAP) among orphaned adolescents with plaque-induced gingivitis.

Methods: A total of ninety adolescents were randomly selected and allocated into three different groups. Group A received the pamphlet (n = 30), Group B received the cartoon animated video (n = 30), and Group C received the caregiver-supervised training (n = 30).

Impact of maternal thyroid dysfunction on fetal and maternal outcomes in pregnancy: a prospective cohort study.

Background: Thyroid dysfunction in pregnancy can adversely impact maternal and fetal outcomes. However, the association between thyroid status and specific adverse outcomes needs clarity, especially in understudied regions.

Objective: This prospective cohort study aimed to illuminate the multifaceted associations between maternal thyroid dysfunction and feto-maternal outcomes in Gujarat, India.

Analysis of systemic serum vancomycin levels following intraarticular application in primary total joint arthroplasty.

Introduction: Periprosthetic joint infection (PJI) is a serious complication following primary total joint arthroplasty (TJA). PJI accounts for 15-25% of revision surgeries, therefore it is associated with PJI is associated with substantial patient morbidity and mortality as well as increased healthcare expenditures due to complex treatment strategies. Recently, intraoperative local application of vancomycin powder is increasingly being used in primary total hip and knee arthroplasty (THA, TKA) as an additive strategy for PJI prevention.

Emerging Biomarkers for Assessing Thrombotic Risk in Patients Receiving Direct Oral Anticoagulants (DOACs).

Direct Oral Anticoagulants (DOACs) have transformed the management of thrombotic disorders, offering a more convenient and effective alternative to traditional vitamin K antagonists (VKAs). However, assessing thrombotic risk in patients treated with DOACS remains crucial due to the potential for recurrent events. Current clinical risk scores have limitations in predicting and monitoring venous thromboembolism (VTE) risk in specific DOAC populations.

Enhancing diabetic retinopathy and macular edema detection through multi scale feature fusion using deep learning model.

Background: This work tackles the growing problem of early identification of diabetic retinopathy and diabetic macular edema. The deep neural network design utilizes multi-scale feature fusion to improve automated diagnostic accuracy. Methods This approach uses convolutional neural networks (CNN) and is designed to combine higher-level semantic inputs with low-level textural characteristics.

A Rare Case of Non-ossifying Fibroma Causing Pathological Subtrochanteric Femur Fracture in a Child: A Common Lesion at an Uncommon Location.

Non-ossifying fibroma (NOF) is a benign expansive lytic lesion more frequently found in children and adolescents at the metaphysis of long bones in and around the knee joint, typically resolving spontaneously or by ossification. This report presents a rare case of an 11-year-old child with a pathological subtrochanteric femur fracture attributed to an underlying NOF. We describe the diagnosis and surgical management of curettage and internal fixation using a proximal humerus locking plate, resulting in complete resorption of the lytic zone and an excellent clinical outcome.

S. Padmavati: The Trailblazing Pioneer of Cardiovascular Medicine in India.

Dr. S. Padmavathi Iyer is a distinguished cardiologist recognized for her expertise in cardiovascular medicine.

Promoting self-care and improving quality of life in cardiovascular disease patients: The role of pharmacist-led interventions in community pharmacies.

Background: Community pharmacists are underutilized in assisting patients with cardiovascular diseases within pharmacy settings. Monitoring and controlling cardiovascular risks could prevent deaths globally and save public health expenses. The aim of this study is to verify how self-care can impact the quality of life of patients with cardiovascular diseases.

Diagnostic accuracy of Fatty Liver Index (FLI) for detecting Metabolic Associated Fatty Liver Disease (MAFLD) in adults attending a tertiary care hospital, a cross-sectional study.

Background: Metabolic-associated fatty liver disease (MAFLD) is a major public health problem worldwide. This study aimed to determine the prevalence of MAFLD and evaluate the diagnostic accuracy of the Fatty Liver Index (FLI) compared to ultrasonography for detecting fatty liver in adults attending a tertiary care hospital in Gujarat, India.

Methods: This cross-sectional study included 500 adults visiting the outpatient department between January 2023 and December 2023.

Evaluation of Effect of Laser in Root Canal Disinfection in Pulp Regenerative Therapy: A Systematic Review.

The evaluation of the effect of laser in disinfection of root canal in pulp regenerative therapy, if found effective laser can be used for root canal disinfection in cases of regenerative endodontic therapy. This study includes a systematic review addressing the question of whether laser is effective in root canal treatment in regenerative endodontic therapy. Randomized controlled trials (RCTs), case series, and animal studies evaluating the effect of laser-assisted endodontic irrigation in pulp regenerative therapy were included.

Enhancing AppAuthentix recommender systems using advanced machine learning techniques to identify genuine and counterfeit android applications.

Smartphone app expansion needs strict security measures to avoid fraud and danger. This study overcomes this issue by identifying apps differently. This new solution uses convolutional neural network (CNN), natural language processing (NLP), and the strong AppAuthentix Recommender algorithm to secure app stores and boost customer confidence in the digital marketplace.

New records of the primarily Sri Lankan Pseudophilautus regius (Manamendra-Arachchi & Pethiyagoda, 2005) (Amphibia; Rhacophoridae) from the Eastern Ghats of India, crossing the Palk Strait saltwater barrier in the Indian Ocean.

Pseudophilautus regius is a bush frog originally described from the dry zones of Sri Lanka. In the present study, P. regius is being reported from the Eastern Ghats of Andhra Pradesh, India as a new record for the country.

Caproic acid production is linked to biomass activity during xylose fermentation.

This study aims at addressing inconsistencies in literature regarding the organic loading rate (OLR) and hydraulic retention time (HRT) effect on caproic acid production, using biomass activity as an indicator. Xylose was fully consumed in the reference CSTR and SBR (HRT = 1-day; OLR = 12 gCOD/(L·d)), but different caproic acid yields (0.02 vs 0.

A Case Study of Umbilical Hernia Complicated by the Presence of a Desmoid Tumor.

Desmoid tumors or aggressive fibromatosis are locally aggressive benign tumors. These arise anywhere in the body but are commonly seen in the anterior abdominal wall. The main treatment choices are continuous surveillance, adjuvant chemotherapy, surgery, and postoperative chemotherapy.

Comparative Analytical Study of Intravitreal Triamcinolone Acetonide Versus Bevacizumab in Managing Diabetic Macular Edema: Insights From a Tertiary Eye Care Facility in India.

Aim: This study aims to compare the effects of intravitreal triamcinolone acetonide (IVTA) and bevacizumab (IVB) in diabetic macular edema (DME) management.

Methodology: A prospective interventional study was conducted at a tertiary eye care hospital in Tamil Nadu, India. The study received approval from the institutional ethics committee, and informed consent was obtained from all participants.

Circulating Extracellular Vesicles as Promising Biomarkers for Precession Diagnostics: A Perspective on Lung Cancer.

Extracellular vesicles (EVs) have emerged as promising biomarkers in liquid biopsy, owing to their ubiquitous presence in bodily fluids and their ability to carry disease-related cargo. Recognizing their significance in disease diagnosis and treatment, substantial efforts have been dedicated to developing efficient methods for EV isolation, detection, and analysis. EVs, heterogeneous membrane-encapsulated vesicles secreted by all cells, contain bioactive substances capable of modulating recipient cell biology upon internalization, including proteins, lipids, DNA, and various RNAs.

A Study of Disability Severity, Barriers, and Facilitating Factors in Accessing Healthcare Among Differently Abled Adults.

Background: Disability impacts many individuals, thus restricting access to necessary healthcare. Barriers that affect health equity among people with disabilities include physical inaccessibility, financial constraints, and stigma in society. This study aims to report on the level of disability and factors determining healthcare access among adult differently abled persons in Chennai, Tamil Nadu, focusing on the WHO Disability Assessment Schedule (WHODAS 2.