Publications by authors named "Domas Vaitiekus"
Article Synopsis
- Hematopoietic stem cell transplantation (HSCT) is a treatment for blood cancers that can potentially cure patients, but it is linked to increasing cases of cardiac dysfunction over time.
- A study of 55 HSCT patients found that 27.3% developed asymptomatic cardiac dysfunction one year post-transplant, with some classified as having moderate or mild dysfunction.
- Key factors associated with increased risk of cardiac dysfunction included previous use of anthracyclines and undergoing the BEAM chemotherapy regimen as part of the conditioning process before HSCT.
Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk of cardiovascular diseases. In our study, we aimed to find subclinical changes in myocardial tissue after HSCT with the help of cardiovascular magnetic resonance (CMR) tissue imaging techniques. The data of 44 patients undergoing autologous and allogeneic HSCT in the Hospital of Lithuanian University of Health Sciences Kaunas Clinics from October 2021 to February 2023 were analyzed.
View Article and Find Full Text PDFThe hematopoietic stem cell transplantation (HSCT) process is known to cause cardiac toxicity of different grades. In this paper, we aimed to evaluate the impact of mobilization procedure of hematopoietic stem cells for autologous HSCT process for left and right ventricle sizes and functions. The data of 47 patients undergoing autologous HSCT were analyzed.
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- - The study investigated how cancer patients' behaviors, tracked via smartphone sensors, were related to their fear of COVID-19 and their vaccination status, involving 202 patients from August 2022 to August 2023.
- - Results showed that most patients were vaccinated, with fully or unvaccinated individuals displaying greater fear of COVID-19 compared to those partially vaccinated; fear levels were notably higher among patients undergoing biological therapies.
- - Behavior analysis indicated that patients with higher COVID-19 fear were less mobile, spending more time at home and visiting fewer places, while vaccinated patients engaged in more outings compared to unvaccinated ones.
Background: Timely recognition of cancer progression and treatment complications is important for treatment guidance. Digital phenotyping is a promising method for precise and remote monitoring of patients in their natural environments by using passively generated data from sensors of personal wearable devices. Further studies are needed to better understand the potential clinical benefits of digital phenotyping approaches to optimize care of patients with cancer.
View Article and Find Full Text PDFBackground: Cardiac side effects associated with anthracycline-based treatment may seriously compromise the prognosis of patients with breast cancer (BC). Evidence shows that genes that operate in drug metabolism can influence the risk of anthracycline-induced cardiotoxicity (AIC). ATP-binding cassette (ABC) transporters could serve as one of the potential biomarkers for AIC risk stratification.
View Article and Find Full Text PDF. The most important anthracycline side effect is cardiotoxicity, resulting in congestive heart failure (HF). Early detection of cardiac dysfunction and appropriate treatment can improve outcomes and reduce the progression of HF.
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- - Mediastinal neuroendocrine tumors are rare but aggressive cancers that often remain undetected until they reach advanced stages, leading to a poor prognosis.
- - A case study involved a 74-year-old man who underwent successful coronary bypass surgery and simultaneous removal of a large mediastinal tumor found during preoperative checks.
- - Although surgery is the preferred treatment, relapse rates can be high, especially for atypical tumors, yet the patient has been on chemotherapy for 49 months post-operation despite ongoing challenges.
Purpose: Breast cancer is the most frequent female cancer, leading to relapse with distant metastasis of approximately one-third of patients. Cancer is usually considered a genetic disease involving mutations in nuclear DNA. However, genes, coding for mitochondrial proteins or regulatory molecules, are rarely under consideration.
View Article and Find Full Text PDFProgress in oncology has allowed to improve outcomes in many breast cancer patients. The core stone of breast cancer chemotherapy is anthracycline-based chemotherapy. Unfortunately, anthracyclines cause cardiotoxicity which is a limiting factor of its use and lifetime cumulative dose of anthracyclines is the major risk factor for cardiotoxicity.
View Article and Find Full Text PDFAdvances in oncologic therapies have allowed to achieve better outcomes and longer survival in many patients with breast cancer. Anthracyclines are cytotoxic antibiotics widely used in daily oncology practice. However, anthracyclines cause cardiotoxicity which is a limiting factor of its use.
View Article and Find Full Text PDFBackground: Undifferentiated pleomorphic sarcoma is a very rare and aggressive type of primary cardiac tumors. Most cardiac sarcomas result in rapid growth and quick death. According to different sources the median survival is typically 6 to 12 months.
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