Cognitive Reserve as a Protective Factor of Mental Health in Middle-Aged Adults Affected by Chronic Pain.

Chronic pain is associated with worse mental health and cognitive impairment, which can be a cause or a consequence of brain structure and function alterations, e.g., maladaptive plasticity, antinociceptive system dysregulation.

Transcranial Direct Current Stimulation and Visual Illusion Effect According to Sensory Phenotypes in Patients With Spinal Cord Injury and Neuropathic Pain.

Treatment of neuropathic pain (NP) in patients with spinal cord injury (SCI) remains a major challenge. The aim of the present study is to investigate if the effect of transcranial direct current stimulation combined with visual illusion, following a previously published protocol, has differential effects on pain-related sensory symptoms according to sensory phenotypes profiles. One hundred and thirty SCI patients with NP participated in this open-label trial.

Quality of Life After Brain Injury: Psychometric Properties of the Spanish Translation of the QoLIBRI.

Traumatic brain injury (TBI) is frequently followed by a variety of physical, emotional, and cognitive symptoms, which affect the patient's daily life, their social relations, and their work/educational status. In addition to function measures, health-related quality of life (HRQoL) has received increasing attention as an important outcome after TBI, as it may guide rehabilitation and evaluate treatment success. Here, we report on psychometric properties of a Spanish translation of the quality of life after brain injury (QoLIBRI) questionnaire, a disease-specific instrument to assess HRQoL in patients after TBI.

Gestural Interaction and Visual Illusion for Lower Limbs' Neuropathic Pain Treatment.

Pain caused by a lesion or a disease affecting the somatosensory nervous system is known as Neuropathic pain. It has been shown that neuropathic pain can be treated with the combination of simultaneous transcranial direct current stimulation and the generation of the visual illusion that the patient retains control of the affected limbs. For persons with neuropathic pain in the lower limbs, the visual illusion consists of an image of the patient walking normally.

Depression in Individuals With Traumatic and Nontraumatic Spinal Cord Injury Living in the Community.

Objective: To assess depression in a sample of individuals with spinal cord injury (SCI) living in the community, and to determine the prevalence of probable major depressive disorder (PMDD) among those with traumatic spinal cord injury (T-SCI) and those with nontraumatic spinal cord injury (NT-SCI).

Design: Cross-sectional.

Setting: Data were collected on individuals with SCI now living in the community, who completed a comprehensive follow-up assessment at the hospital.

Meta-analysis of placebo responses in central neuropathic pain: impact of subject, study, and pain characteristics.

The placebo response is a complex construct related to psychobiological effects, as well as natural history and regression to the mean. Moreover, patient and study design characteristics have also been proposed as significantly affecting placebo responses. The aim of the current investigation was to identify factors that contribute to variable placebo responses in clinical trials involving individuals with central neuropathic pain.

Evoked potentials and quantitative thermal testing in spinal cord injury patients with chronic neuropathic pain.

Objective: Neuropathic pain (NP) is a common symptom following spinal cord injury (SCI). NP may be associated with altered processing of somatosensory pathways in dermatomes rostral to the injury level. To explore this possibility, the characteristics of contact heat evoked potentials (CHEPs) and quantitative thermal testing (QTT) were studied at and above the lesion level in SCI patients with NP.

Knowledge discovery about quality of life changes of spinal cord injury patients: clustering based on rules by states.

In this paper, an integral Knowledge Discovery Methodology, named Clustering based on rules by States, which incorporates artificial intelligence (AI) and statistical methods as well as interpretation-oriented tools, is used for extracting knowledge patterns about the evolution over time of the Quality of Life (QoL) of patients with Spinal Cord Injury. The methodology incorporates the interaction with experts as a crucial element with the clustering methodology to guarantee usefulness of the results. Four typical patterns are discovered by taking into account prior expert knowledge.