Production of Two Isomers of Sphaeralcic Acid in Hairy Roots from .

The plant is used as an anti-inflammatory and gastrointestinal protector in Mexican traditional medicine. The immunomodulatory and anti-inflammatory effects have been attributed to scopoletin (), tomentin (), and sphaeralcic acid () isolated from cells in suspension cultures and identified in the aerial tissues of the wild plant. The hairy roots from established by infecting internodes with were explored to produce active compounds based on biosynthetic stability and their capacity to produce new compounds.

Clinical trial for evaluating the effectiveness and tolerability of topical Sphaeralcea angustifolia treatment in hand osteoarthritis.

Ethnopharmacological Relevance: Sphaeralcea angustifolia Cavanilles & Don (Malvaceae), known in Mexico as "Vara de San José", is used in Mexican Traditional Medicine as an anti-inflammatory and, more specifically, for treating rheumatism. Anti-inflammatory properties have been demonstrated in different pharmacological models.

Aim Of The Study: The therapeutic effectiveness and tolerability of the topical administration of a gel elaborated with a standardized Sphaeralcea angustifolia extract applied to patients with Hand osteoarthritis (HOA) was evaluated.