Publications by authors named "Dolores Lopez-Villegas"
Article Synopsis
- Alcohol consumption is linked to cognitive impairment in individuals aged 60 and older, with both excessive and moderate drinking influencing cognitive health.
- A systematic review of studies from 2010 to 2020 identified that excessive and prolonged alcohol use can lead to serious forms of dementia and cognitive impairment, citing notable disorders like Wernicke-Korsakoff syndrome.
- The cognitive functions most impacted by alcohol use disorder include executive functions, visuospatial skills, attention, and memory, emphasizing the risks associated with high levels of alcohol intake.
Atypical astroglial pTDP-43 pathology in astroglial predominant tauopathy.
Neuropathol Appl Neurobiol
December 2021
We observed atypical astrocytic pTDP-43 pathology in astroglial predominant tauopathy.
View Article and Find Full Text PDFThe neuropathological hallmark of the C9orf72 intronic hexanucleotide expansion in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) is the presence of small ubiquitin/p62-positive and transactive response DNA binding protein 43 kDa (TDP-43)-negative cytoplasmic inclusions in several brain areas. The identification of this histopathological signature is highly predictive of an underlying mutation. In this study, we screened 1800 cases of the Barcelona IDIBAPS Brain Bank, independently of the clinical and final neuropathological diagnosis of the brain donor, for the presence of ubiquitin/p62-positive inclusions in the cerebellum (UPPI).
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