[Genetic thrombophilia and markers of endothelial activation in patients with preeclampsia].

Background: The presence of thrombosis in preeclampsia suggests that endothelial function could play an important role in its pathogenesis.

Objective: Determine the association between markers of genetic thrombophilia, endothelial activation and preeclampsia.

Material And Method: Prospective study of cases and controls to determine the factor V Leiden existence, protrombin G20210A, methylenetetrahydrofolate reductase C677T, activated protein C resistance and levels of von Willebrand factor and the sFlt1 receptor were determined in 28 women with preeclampsia and 41 pregnant controls.