Publications by authors named "Dolly Noun"
Article Synopsis
- * A case study of a 12-year-old girl revealed NF2 when she presented with abdominal pain, leading to the discovery of a benign nerve sheath tumor in her gallbladder that mimicked atypical symptoms.
- * This case highlights the importance of recognizing uncommon manifestations of NF2 for early diagnosis and treatment, and it emphasizes the need for a collaborative approach in patient management.
Treatment outcomes in retinoblastoma and the effect of tumor topography.
Pediatr Blood Cancer
December 2024
Background: Retinoblastoma, the most common intraocular malignancy in children, has high fatality rates if untreated. It is crucial to monitor treatment effectiveness and explore factors influencing favorable outcomes. Our study aims to examine how tumor location impacts the response to standard treatments and the achievement of favorable outcomes among retinoblastoma patients, while controlling for other tumor-related factors.
View Article and Find Full Text PDFBackground: The Pediatric Oncology East and Mediterranean (POEM) group that aims to share expertise among pediatric oncology providers across the Middle East, North Africa, and East Asia region initiated a virtual Case Discussion Forum (CDF) in 2013.
Methods: Meeting records from September 2013 till June 2021 were reviewed. Detailed minutes were available starting August 2016; case data were analyzed including diagnoses, purpose of presentation and recommendations.
Brucellosis is one of the most prevalent zoonotic infections in the Middle East. The disease may present with a range of symptoms from a simple febrile illness to severe invasive infections affecting different organ systems (meningitis, osteomyelitis). In this paper we present an eleven-year-old girl who was diagnosed with "idiopathic bone marrow aplasia" and planned for hematopoietic stem cell transplant (HSCT), when pre-transplant work-up showed high brucella titers.
View Article and Find Full Text PDFArticle Synopsis
- Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) is a rare leukemia in children, known for its high relapse rate despite being sensitive to chemotherapy.
- Targeted therapies like Tagraxofusp and Venetoclax have shown promising results in treating BPDCN, including in relapsed cases.
- A pediatric patient case is presented, highlighting treatment with an ALL-based regimen and subsequent Allogeneic hematopoietic stem-cell transplantation, followed by salvage therapy with Hyper-CVAD and Venetoclax after a testicular relapse.
The interleukin-7 receptor (IL-7R) is expressed on lymphoid cells and plays an important role in the development, homeostasis, survival, and proliferation of T cells. Bi-allelic mutations in the IL-7Rα chain abolish T cell development and function resulting in severe combined immunodeficiency disease. In this manuscript, we investigate a 1 year-old patient born to consanguineous parents, who suffered from autoimmune hemolytic anemia since birth associated with recurrent severe infections.
View Article and Find Full Text PDFBackground: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary immunodeficiency disorder (PID) characterized by microthrombocytopenia, bloody diarrhea, eczema, recurrent infections, and a high incidence of autoimmunity and malignancy.
Objective: To investigate the mechanism of thrombocytopenia and infections in four boys of consanguineous parents from Lebanon.
Methods: Patient gDNA was studied using Next Generation Sequencing and Sanger Sequencing.