Mitigating CYP3A4-mediated aflatoxin toxicity with algal-derived Sodium Copper Chlorophyllin: Production and In-silico insights.

The present research explores the cytotoxic mechanism of protein Cytochrome P450 (CYP3A4) with aflatoxin (AFB1), a potent carcinogen. Cytochrome P450 is an essential enzyme involved in drug metabolism, however epoxide formation due to the binding event of AFB1 leads to cell cytotoxicity. In this direction, our study elucidates the scavenging effect of algal-derived Sodium Copper Chlorophyllin (SCC) over AFB1 cytotoxicity.

Kynurenic acid as a biochemical factor underlying the association between Western-style diet and depression: A cross-sectional study.

Consumption of a Western-style diet (WS-diet), high in saturated fat and added sugar, is associated with increased depression risk. However, the physiological mechanisms underlying the relationship requires elucidation. Diet can alter tryptophan metabolism along the kynurenine pathway (KP), potentially linking inflammation and depression.

Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet.

Animals fed a Western-style diet (WS-diet) demonstrate rapid impairments in hippocampal function and poorer appetitive control. We examined if this also occurs in humans. One-hundred and ten healthy lean adults were randomized to either a one-week WS-diet intervention or a habitual-diet control group.

A brief diet intervention can reduce symptoms of depression in young adults - A randomised controlled trial.

There is strong epidemiological evidence that poor diet is associated with depression. The reverse has also been shown, namely that eating a healthy diet rich in fruit, vegetables, fish and lean meat, is associated with reduced risk of depression. To date, only one randomised controlled trial (RCT) has been conducted with elevated depression symptoms being an inclusion criterion, with results showing that a diet intervention can reduce clinical levels of depression.

Effect of malnutrition on the digestive enzymes of the upper gastrointestinal tract of young rhesus monkeys.

The present study was planned to observe the effect of protein-energy malnutrition on the gastric and duodenal mucosa. The activities of digestive enzymes (i.e.