Immunocytes modulate ganglionic nitric oxide release which later affects their activity level.

Pedal ganglia excised and maintained in culture for up to 2 h, release NO at low levels. The range can vary between 0 to 1.1 nM.

Nitric oxide modulates microglial activation.

Background: Nitric oxide (NO) has important physiological regulatory roles, i.e, vasodilation, neurotransmitter release, etc. Little is known about the processes in neural tissues, which stabilize microglia.

The presence of 17-beta estradiol in Mytilus edulis gonadal tissues: evidence for estradiol isoforms.

Objectives: In earlier studies, we demonstrate that 17-beta -estradiol and an estrogen cell surface receptor can be found on various human cells, i.e., vascular endothelial, monocytes, and granulocytes, where they are coupled to nitric oxide release.

17-beta estradiol down regulates ganglionic microglial cells via nitric oxide release: presence of an estrogen receptor beta transcript.

Objectives: In earlier studies we have demonstrated that 17-beta-estradiol and an estrogen cell surface receptor can be found on various human cells where they are coupled to nitric oxide release. We also demonstrated the presence of estrogen signaling in Mytilus edulis ganglia. In the present report, we sought to determine a function for these ganglionic estrogen receptors, transcending a reproductive role for estrogen.

Risk factors for breast cancer and the prognosis of African American women: estrogen's role.

Archival reports demonstrate that black females are in the minority of reported breast cancer cases, yet are given a significantly poorer prognosis than their white counterparts. Numerous studies have been conducted in an attempt to explain this discrepancy. In the past, socio-economic variables such as economic status and access to adequate health care have been the focus of attention.

Estrogen signaling at the cell surface coupled to nitric oxide release in Mytilus edulis nervous system.

In previous studies we have demonstrated release of nitric oxide (NO) in human tissues following exposure to estrogen. We now designed experiments to determine whether estrogen is present in the neural tissue of Mytilus edulis, a marine mollusk, and whether, as in vertebrates, it stimulates constitutive NO synthase activity. After HPLC purification of 17beta-estradiol (17beta-E(2)) from M.