Publications by authors named "Dohyeon An"
Background: To compare the visual efficacy and patient satisfaction between 2 toric IOLs (TIOL), enhanced for intermediate vision or monofocal.
Methods: A retrospective chart review was performed of 100 eyes from 68 astigmatic patients who underwent cataract surgery with implantation of a Tecnis Eyhance Toric II IOL (Johnson & Johnson Vision, Irvine, CA, USA) (Group 1, 50 eyes) or Tecnis TIOL (Group 2, 50 eyes). The uncorrected distant (UDVA), intermediate (UIVA), and near (UNVA) visual acuities; residual refractive astigmatism; defocus curve; and IOL axis rotation were evaluated at 1 week, 1 month, 2 months, and 3 months postoperatively.
Article Synopsis
- - The study assesses how changes in the effective lens position (ELP) affect the rotation of toric intraocular lenses (IOLs) in patients who develop increased astigmatism after surgery.
- - Researchers examined 61 patients over three months, finding that postoperative astigmatism increased, and significant changes in ELP and IOL rotation occurred during this period.
- - Positive correlations were identified between changes in ELP and both IOL rotation and postoperative astigmatic changes, indicating that variations in lens position can lead to greater residual astigmatism following toric IOL implantation.
Article Synopsis
- The study examines the intricate relationship between tumor cells and their surrounding normal tissue by analyzing a vast dataset of single-cell and spatial transcriptomes from various cancer samples.
- Researchers identify different cellular states within the tumor ecosystem and their associated gene signatures, highlighting specific interactions and spatial patterns among cells like inflammatory fibroblasts.
- The findings suggest that certain immune cell communities, particularly those enriched with interferon, respond better to immunotherapy, offering new insights into the variability of cancer treatment responses.
Identification of optimal target antigens that distinguish cancer cells from normal surrounding tissue cells remains a key challenge in chimeric antigen receptor (CAR) cell therapy for tumors with intratumoral heterogeneity. In this study, we dissected tissue complexity to the level of individual cells through the construction of a single-cell expression atlas that integrates ~1.4 million tumor, tumor-infiltrating normal and reference normal cells from 412 tumors and 12 normal organs.
View Article and Find Full Text PDFHyperglycemia is a hallmark of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Recent evidence strongly suggests that prolonged exposure to hyperglycemia can epigenetically modify gene expression profiles in human cells and that this effect is sustained even after hyperglycemic control is therapeutically achieved; this phenomenon is called hyperglycemic memory. This metabolic memory effect contributes substantially to the pathology of various diabetic complications, such as diabetic retinopathy, hypertension, and diabetic nephropathy.
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