Assessment of fishes, sediment and water from some inland rivers across the six geopolitical zones in Nigeria for microplastics.

In Nigeria, limited research has been conducted on Microplastics (MPs) in inland rivers, necessitating a comprehensive assessment to understand the extent of contamination. This study aimed to assess the abundance, distribution, and composition of MPs in fishes, sediment, and water from inland rivers across Nigeria's six geopolitical zones. Samples were collected from selected rivers in each geopolitical zone (Rivers Yauri, Benue, Argungu, Jamare, Ogun, Ethiope and Orashi).

Influence of a Dispersant on the Types and Growth of Microbial Hydrocarbon Degraders in a Crude Oil-contaminated Medium.

Background: Dispersants are first order response strategies for oil spill cleanup in an aquatic environment. However, their effects on the biodegradation capacity of indigenous hydrocarbon-degrading microorganisms are little known.

Objectives: The influence of a dispersant (DS/TT/066) on the type(s) and growth of hydrocarbon-degrading bacteria (HDB) and hydrocarbon-degrading fungi (HDF) in a crude oil-contaminated medium (water) was investigated in the laboratory for 28 days.

Occurrence and distribution of monocyclic aromatic hydrocarbons (BTEX) and the impact on macrobenthic community structure in Lagos lagoon, Nigeria.

The widespread distribution of petroleum products arising from the rapid growth of the petroleum industry in Nigeria has resulted in the pollution of the environment through oil spills involving leakages from tankers, pipelines, tank farms, and dumping of waste petroleum products. The impacts and distribution of major toxic components (benzene, toluene, ethylbenzene, and xylene (BTEX)) of petroleum products in water and sediment samples collected from sampling stations in the Lagos lagoon was investigated over a 2-year period (February 2009-July 2010). The distribution of benthic communities in the different sampling stations of the Lagos lagoon was assessed.

Histopathological alterations, biochemical responses and acetylcholinesterase levels in Clarias gariepinus as biomarkers of exposure to organophosphates pesticides.

Organophosphate pesticides, commonly used in large scale farming, have been found to be major contaminants in aquatic environment. Clarias gariepinus was exposed to acute and sublethal concentrations of phostoxin and DD Force to evaluate single and joint action toxicity of the organophosphates. Effects of phostoxin and DD force on antioxidant enzymes, fish organs and acetylcholinesterase levels in fingerlings and juveniles of C.

Cutaneous Mycobacterium chelonae infection in Edinburgh and the Lothians, South-East Scotland, U.K.

Background: We reviewed all cases of Mycobacterium chelonae infection seen in our department between 1 January 2008 and 31 December 2012.

Objectives: To review the epidemiology, clinical features and management of cutaneous M. chelonae in South-East Scotland, and to compare prevalence data with the rest of Scotland.

Reprint of: environmental information for military planning.

A study was conducted to consider the implications of presenting Environmental Information (EI; information on current environmental features including weather, topography and visibility maps) for military planning to the growing audience of non-technical users; to provide guidance for ensuring usability and for development of a suitable EI interface, and to produce an EI concept interface mock-up to demonstrate initial design ideas. Knowledge was elicited from current EI users and providers regarding anticipated use of EI by non-specialists. This was combined with human factors and cognition expertise to produce guidance for data usability and development of an EI interface.

Environmental information for military planning.

A study was conducted to consider the implications of presenting Environmental Information (EI; information on current environmental features including weather, topography and visibility maps) for military planning to the growing audience of non-technical users; to provide guidance for ensuring usability and for development of a suitable EI interface, and to produce an EI concept interface mock-up to demonstrate initial design ideas. Knowledge was elicited from current EI users and providers regarding anticipated use of EI by non-specialists. This was combined with human factors and cognition expertise to produce guidance for data usability and development of an EI interface.

DNA repair and replication proteins as prognostic markers in melanoma.

Aims:   Elevated expression of DNA repair and replication genes has been reported in thick, non-fixed primary melanomas that subsequently went on to metastasize, when compared to non-recurrent primary tumours. This increased expression could contribute to the extreme resistance shown by melanoma to DNA-damaging chemotherapeutics. We have investigated the hypothesis that levels of key DNA repair and replication proteins are prognostic biomarkers in melanoma.

Monitoring of soil and groundwater contamination following a pipeline explosion and petroleum product spillage in Ijegun, Lagos Nigeria.

In May 2008, an accidental damage of a Nigerian National Petroleum Corporation (NNPC) pipeline occurred in Ijegun area of Lagos, Nigeria, resulting in oil spillage and consequent contamination of the environment. The residual concentration of the total hydrocarbon (THC) and benzene, toluene, ethylbenzene, and xylene (BTEX) in the groundwater and soil was therefore investigated between March 2009 and July 2010. Results showed elevated THC mean levels in groundwater which were above the World Health Organization maximum admissible value of 0.

Histopathology alterations and lipid peroxidation as biomarkers of hydrocarbon-induced stress in earthworm, Eudrilus eugeniae.

This study investigated the biomarker responses of the earthworm, Eudrilus eugeniae, exposed to sublethal concentrations of benzene, toluene and xylene (BTX) for a time span of 28 days. Lipid peroxidation (LPO) and histopathological alterations were examined. Toxicological evaluations of BTX were carried out against E.

Differential expression of microRNAs during melanoma progression: miR-200c, miR-205 and miR-211 are downregulated in melanoma and act as tumour suppressors.

Background: The incidence of malignant melanoma is increasing faster than that for any other cancer. Histological examination of skin excision biopsies remains the standard method for melanoma diagnosis and prognosis. Significant morphological overlap between benign and malignant lesions complicates diagnosis, and tumour thickness is not always an accurate predictor of prognosis.

Association of galectin-3 expression with melanoma progression and prognosis.

Aims: Galectin-3 plays an important role in adhesion, proliferation, differentiation, angiogenesis and metastasis in multiple tumours. To investigate the role of galectin-3 in melanoma pathogenesis we examined the expression of galectin-3 in melanocytic lesions and analysed the correlation between galectin-3 expression and clinicopathologic factors including patient survival and BRAF mutation status.

Methods: We evaluated the expression of galectin-3 in 53 cases of benign naevi, 31 cases of dysplastic naevi, 59 in-situ melanomas, 314 cases of primary melanoma and 69 metastatic melanomas using tissue microarray and immunohistochemistry.

Women's perceptions of the effects of menopause and hormone replacement therapy on skin.

Although women frequently associate skin issues with menopause and hormone replacement therapy (HRT), little work has been done to investigate a possible relationship. A questionnaire was given to women attending a specialist menopause clinic; 87 women responded. Skin problems generally were common, with over 64% of respondents reporting past problems.

Trends in skin cancer incidence by socioeconomic position in Scotland, 1978-2004.

Background: Non-melanoma skin cancer has been little studied in relation to deprivation.

Methods: Incident cases diagnosed in 1978-2004 were extracted from the Scottish Cancer Register and assigned to quintiles of Carstairs deprivation scores. Age-standardised incidence rates (ASRs) (European standard population) were calculated by deprivation quintile, sex, period of diagnosis, for the three main types of skin cancer.

Recent trends in incidence of nonmelanoma skin cancers in the East of Scotland, 1992-2003.

Background: Historically, ascertainment of nonmelanoma skin cancer (NMSC) by cancer registries in the U.K. has been shown to be incomplete in several studies.

Melanoma incidence and mortality in Scotland 1979-2003.

We studied 12,450 cases of invasive melanoma diagnosed in Scotland in 1979-2003, by thickness, pathological type, and body site at ages under 40, 40-59, and 60 years and over. Melanoma incidence trebled in males from 3.57 to 10.

Changes in the site distribution of malignant melanoma in South East Scotland (1979-2002).

Scottish Melanoma Group (SMG) data on 2790 melanoma (MM) cases in South East Scotland over a 24-year time period were analysed in four periods each of 6 years duration grouped into frequently exposed, intermittently exposed, and always covered sites. Incidence increased significantly over time with females having a higher incidence rate than males. In both sexes, the proportion of cases seen on the posterior trunk and arm increased significantly (P<0.

DNA repair gene polymorphisms and genetic predisposition to cutaneous melanoma.

The incidence of cutaneous melanoma is rising rapidly in a number of countries. The key environmental risk factor is exposure to the ultraviolet (UV) component in sunlight. The nucleotide excision repair (NER) pathway deals with the main forms of UV-induced DNA damage.

Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction.

Idiopathic fetal growth restriction (FGR) is often associated with placental insufficiency. Previously, we isolated and characterized homeobox gene DLX4 from the placenta and provided evidence that DLX4 may regulate placental development. Here, we have investigated whether DLX4 expression levels were altered in idiopathic FGR.

The -56T HLA-G promoter polymorphism is not associated with pre-eclampsia/eclampsia in Australian and New Zealand women.

Objective: Decreased HLA-G expression has been linked to a number of pregnancy disorders, including preeclampsia, and a genetic basis for HLA-G regulation has yet to be found. The aim of this study was to determine whether a C-to-T base substitution 56 base pairs (bp) upstream from the HLA-G transcription start site is associated with preeclampsia.

Methods: 277 nulliparous women consisting of 113 normotensive, 118 preeclamptic, and 46 eclamptic patients were typed for the -56T polymorphism using restriction fragment length polymorphism and allelic discrimination analysis.