Feasibility and effectiveness of telerehabilitation on mobility and balance function in multiple sclerosis: A systematic review and meta-analysis.

Background: Multiple Sclerosis (MS) is a chronic neurodegenerative disease of the central nervous system with a significant impact on mobility and balance function. Telerehabilitation is an emerging branch of telemedicine which has the potential to deliver rehabilitation remotely through the use of information and communication technology. The aim of this systematic literature review and meta-analysis is to synthesise and analyse the evidence on the effectiveness of telerehabilitation in improving mobility and balance function in MS and to determine its feasibility.

Physical Telerehabilitation interventions for Gait and balance in Multiple sclerosis: A Scoping review.

Background: Gait and balance impairments affects approximately a quarter of people with multiple sclerosis (pwMS) at onset and increases to almost half by five years. Physical rehabilitation has been recognised as the gold standard method to restore physical function in multiple sclerosis (MS). Emerging evidence in the literature is suggesting that a remote therapy rehabilitation platform (Telerehabilitation) is cost-effective, beneficial, and satisfying for patients and health care practitioners.

Age-Friendly and Climate Resilient Communities: A Grey-Green Alliance.

The world's population is aging while the Earth's climate is warming. The climate change crisis poses threats to our aging population and requires concerted action. Steps to address these threats present opportunities for improving livability for people of all ages while addressing the underlying drivers of climate change.

Legal capacity, developmental capacity, and impaired mental capacity in children under 16: Neurodevelopment and the law in Northern Ireland.

When people of any age, despite all possible support being provided, are unable to make a necessary decision, then it is important to have a legal framework which promotes and protects their rights. There is ongoing debate about how this can be achieved, in a non-discriminatory way, for adults but it is also an important consideration for children and young people. In Northern Ireland, the Mental Capacity Act (Northern Ireland) 2016, when fully implemented will provide a non-discriminatory framework for those aged 16 and over.

COVID-19 vaccines uptake: Public knowledge, awareness, perception and acceptance among adult Africans.

Introduction: The willingness of Africa's population to patronise the COVID-19 vaccines is critical to the efficiency of national immunisation programmes. This study surveys the views of adult African inhabitants toward vaccination and the possibility of participating or not participating in governments' efforts to get citizens vaccinated.

Method: A cross-sectional online survey of adult Africans was undertaken from December 2020 to March 2021.

Resident interactions when affirming and correcting peers in a therapeutic community for women.

Purpose –: While recent years have seen a number of studies of social networks in therapeutic communities (TCs) and other residential settings, these have primarily focused on male residents. This paper aims to conduct a longitudinal social network analysis of interpersonal interactions in a TC for women.

Design/methodology/approach –: The data consists of a longitudinal directed social network of instances of feedback between 56 residents of a 16 bed TC for women over a period of 611 days.

Difference in Response to Feedback and Gender in Three Therapeutic Community Units.

Therapeutic communities (TCs) for substance abuse incorporate a system of peer feedback through written affirmations and corrections. Previous research has found that TC residents show a response to affirmations that is detectable for roughly 8 weeks, with response to corrections being of shorter duration and weaker overall. It is not clear whether and to what extent response to feedback in TCs varies between men and women.

Evaluation of knowledge, impacts and government intervention strategies during the COVID - 19 pandemic in Nigeria.

The SARS-CoV-2 is a novel strain of coronavirus which is ravaging many countries, and this has become a global public health concern. With the increasing number of COVID-19 confirmed cases and deaths in Nigeria, the pandemic has led to massive public reactions. This data attempted to evaluate the knowledge, impacts, and government intervention during the pandemic.

Building the community: Endogenous network formation, homophily and prosocial sorting among therapeutic community residents.

Background: Researchers have begun to consider the ways in which social networks influence therapeutic community (TC) treatment outcomes. However, there are few studies of the way in which the social networks of TC residents develop over the course of treatment.

Methodology: We used a Temporal Exponential Random Graph Model (TERGM) to analyze changes in social networks totaling 320,387 peer affirmations exchanged between residents in three correctional TCs, one of which serves men and two of which serve both men and women.

Aerobic microbe community and necrophagous insects associated with decomposition of pig carrion poisoned with lead.

This study investigated the effects of pig feed contaminated with lead (Pb) on the decomposition rate of pig carrion, identified the aerobic microorganisms and necrophagous insects associated with decomposing pig (Sus scrofa) carrion (above ground), and explored their potential use in the determination of post-mortem interval (PMI). The study profiled the decomposition of Sus scrofa carrion over a period of 40 days to record the effects of lead during decomposition. Fungi were identified by sub-culturing on prepared solidified potato dextrose agar and microbial identification was carried out using biochemical characterization.

An Image Analysis Solution For Quantification and Determination of Immunohistochemistry Staining Reproducibility.

With immunohistochemical (IHC) staining increasingly being used to guide clinical decisions, variability in staining quality and reproducibility are becoming essential factors in generating diagnoses using IHC tissue preparations. The current study tested a method to track and quantify the interrun, intrarun, and intersite variability of IHC staining intensity. Our hypothesis was that staining precision between laboratory sites, staining runs, and individual slides may be verified quantitatively, efficiently and effectively utilizing algorithm-based, automated image analysis.

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.

Purpose: Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anticancer small molecule in clinical trials for high-grade gliomas and other malignancies. DRD5 is a dopamine receptor family member that opposes DRD2 signaling. We investigated the expression of these dopamine receptors in cancer and their influence on tumor cell sensitivity to ONC201.

Biodegradation of Pollutants in Waste Water from Pharmaceutical, Textile and Local Dye Effluent in Lagos, Nigeria.

Background: Discharged effluents from industry have been responsible for the deterioration of the aquatic environment in many parts of the world, especially in developing countries. Increasing industrialization and urbanization have resulted in the discharge of large amounts of waste into the environment, resulting in high pollution loads. Utilization of microbes such as fungi and bacteria have been used for pollution degradation.

An evaluation of psychological distress and social support of survivors and contacts of Ebola virus disease infection and their relatives in Lagos, Nigeria: a cross sectional study--2014.

Background: By September 2014, an outbreak of Ebola Viral Disease (EVD) in West African countries of Guinea, Liberia, Sierra Leone, Senegal and Nigeria, had recorded over 4500 and 2200 probable or confirmed cases and deaths respectively. EVD, an emerging infectious disease, can create fear and panic among patients, contacts and relatives, which could be a risk factor for psychological distress. Psychological distress among this subgroup could have public health implication for control of EVD, because of potential effects on patient management and contact tracing.

Positive parenting program (triple P) for families of adolescents with type 1 diabetes: a randomized controlled trial of self-directed teen triple P.

Objectives: Adolescents with type 1 diabetes (T1D) have shown improvements in glycemic control and family relations, via clinic-based family interventions. However, reach and clinician availability may be limited. We evaluated a self-directed intervention for this purpose.

NMDA receptor subunit expression in the supraoptic nucleus of adult rats: dominance of NR2B and NR2D.

The supraoptic nucleus (SON) of the hypothalamus contains magnocellular neurosecretory neurons (MNC) which synthesize and release the peptide hormones vasopressin and oxytocin. Glutamate is a prominent excitatory neurotransmitter in the SON and regulates MNC excitability. NMDA receptors (NMDAR), a type of ionotropic glutamate receptor, mediate synaptic plasticity of MNCs and are necessary for characteristic burst firing patterns which serve to maximize hormone release.

Comparison of the efficacy of four viral vectors for transducing hypothalamic magnocellular neurosecretory neurons in the rat supraoptic nucleus.

Since transgenes were first cloned into recombinant adenoviruses almost 30 years ago, a variety of viral vectors have become important tools in genetic research. Viruses adeptly transport genetic material into eukaryotic cells, and replacing all or part of the viral genome with genes of interest or silencing sequences creates a method of gene expression modulation in which the timing and location of manipulations can be specific. The hypothalamo-neurohypophyseal system (HNS), consisting of the paraventricular (PVN) and supraoptic (SON) nuclei in the hypothalamus, regulates fluid balance homeostasis and is highly plastic, yet tightly regulated by extracellular fluid (ECF) osmolality and volume.

Association of antimicrobial and clinical efficacy: periodontitis therapy with minocycline microspheres.

Objective: The objective of this study was to investigate the association between the antimicrobial and clinical efficacy of minocycline hydrochloride microspheres when used adjunctively with scaling and root planing.

Methods: 127 subjects with moderate-to-advanced chronic periodontitis were randomly assigned to receive either minocycline microspheres plus scaling and root planing (n = 62) or scaling and root planing alone (n = 65). Deoxyribose nucleic acid analysis and clinical data were obtained at baseline and 30 days after treatment.

Cognitive-behavioural therapy for adolescents with bulimic symptomatology: the acceptability and effectiveness of internet-based delivery.

Background: The evidence base for the treatment of adolescents with bulimia nervosa (BN) is limited.

Aims: To assess the feasibility, acceptability, and clinical outcomes of a web-based cognitive-behavioural (CBT) intervention for adolescents with bulimic symptomatology.

Method: 101 participants were recruited from eating disorders clinics or from beat, a UK-wide eating disorders charity.

Effect of storage temperature on the activity of submitochondrial particles.

The submitochondrial particle (SMP) assay employs processed mammalian mitchondria to assess the toxicity of chemical contaminants in aqueous solutions. Particles and associated reagents are commercially available to support two individual procedures, the electron transfer (ETr) and reverse electron transfer (RET) assays. The objective of the present study was to assess the effect of storage temperature on SMP activity.

Mechanical therapy with adjunctive minocycline microspheres reduces red-complex bacteria in smokers.

Background: Smoking increases the risk for periodontal disease and reduces the healing response. We examined the antimicrobial and clinical effects of scaling and root planing (SRP) with and without minocycline HCl 1 mg microspheres (MM) relative to smoking status in subjects with periodontitis.

Methods: A total of 127 subjects (46 never smokers, 44 former smokers, and 37 current smokers) with moderate to advanced periodontitis were randomized to receive MM + SRP (N = 62) or SRP alone (N = 65).

Minocycline HCl microspheres reduce red-complex bacteria in periodontal disease therapy.

Background: The objective of this trial was to measure the antimicrobial effects of a minocycline HCl microsphere (MM) local drug-delivery system when used as an adjunct to scaling and root planing (SRP). DNA probe analysis for 40 bacteria was used to evaluate the oral bacteria of 127 subjects with moderate to advanced chronic periodontitis.

Methods: Subjects were randomly assigned to either SRP alone (N = 65) or MM + SRP (N = 62).

Greatly reduced bioavailability and toxicity of polycyclic aromatic hydrocarbons to Hyalella azteca in sediments from manufactured-gas plant sites.

The toxicity of polycyclic aromatic hydrocarbons (PAHs) to Hyalella azteca, was measured in 34 sediment samples collected from four manufactured-gas plant (MGP) sites ranging in total PAH16 (sum of 16 U.S. Environmental Protection Agency priority pollutant PAHs) concentrations from 4 to 5700 mg/kg, total organic carbon content from 0.

Periodontal treatment by Arestin and its effects on glycemic control in type 1 diabetes patients.

Studies indicate that a dual pathway between diabetes mellitus and periodontal disease exists. Elimination of periodontal infection by using systemic antibiotics in conjunction with scaling and root planing (SRP) improved metabolic control in diabetic patients, as defined by reduction in glycated haemoglobin or reduction in insulin requirements (Grossi and Genco, 1998). The aim of this randomised pilot clinical trial was to determine if type 1 diabetes patients with periodontitis will experience a reduction in HbA1c levels when treated with locally delivered minocycline microspheres (Arestin) as an adjunct to scaling and root planing.