Publications by authors named "Doha Mohammed"
Article Synopsis
- The study aimed to evaluate how omega-3 and vitamin C pretreatment affects liver damage caused by methotrexate in mice.
- Swiss albino mice were divided into five groups, with some receiving methotrexate and others receiving omega-3, vitamin C, or a combination before the methotrexate was administered.
- Results showed that pretreatment with omega-3 and vitamin C significantly reduced liver toxicity, supporting their protective antioxidant properties.
Combination Treatment of Omega-3 Fatty Acids and Vitamin C Exhibited Promising Therapeutic Effect against Oxidative Impairment of the Liver in Methotrexate-Intoxicated Mice.
Mohammed Alorabi Doha Saad Mohammed Gomaa Mostafa-Hedeab Suzy A El-Sherbeni Walaa A Negm Ali Ismail A Mohammed
Biomed Res Int
May 2022
Drug-induced liver injury (DILI) is the main cause of liver damage mediated by the excretion of toxic active drug metabolites. Omega-3 fatty acids and vitamin C have potent antioxidant, anti-inflammatory, and antiapoptotic effects that could offer protection against oxidative stress and liver damage. This study evaluated the hepatoprotective effect of omega-3 and vitamin C alone as well as in a combined form in methotrexate- (MTX-) induced acute liver injury in mice.
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