Publications by authors named "Dogu Vurallı Bakkaloglu"
Amyloidosis is a misfolded protein deposition disorder within the extracellular matrix, leading to dysfunction in the affected organ. Primary amyloidosis manifests as AL and ATTR subtypes, wherein AL is associated with plasma cell dyscrasias. Herein we present a case of a patient who underwent investigation due to the presence of bilateral reticulonodular lung infiltrates, suggestive of miliary tuberculosis.
View Article and Find Full Text PDFWe hereby report a patient with ALK-positive histiocytosis with localized lung involvement. A 47-year-old woman presented with a solitary pulmonary nodule in the left upper lobe, 7 months after COVID infection. A well-defined 15 mm yellow mass was found in trisegmentectomy specimen.
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- The case involves a patient with systemic amyloidosis caused by ankylosing spondylitis, which is a rare complication of this inflammatory disease.
- The diagnostic imaging (99mTc PYP scintigraphy) indicated abnormal amyloid deposits in the thyroid, leading to a condition known as amyloid goiter.
- SPECT/CT scans confirmed the presence of amyloid in an enlarged thyroid gland, showing both diffuse tracer uptake and areas with fat density.
Aim: Idiopathic non-cirrhotic portal hypertension (INCPH) is a vascular disorder of uncertain origin. Diagnosis can be challenging on liver biopsy. Despite diverse histomorphologic findings documented in literature, studies on the frequency of these findings are lacking.
View Article and Find Full Text PDFObjective: Lung adenocarcinomas are divided into acinar, lepidic, papillary, micropapillary, and solid predominant subtypes according to the current World Health Organization (WHO) classification. We designed this retrospective study to demonstrate profiles of MUC expression (MUC1, MUC2, MUC5AC, and MUC6) of different histologic patterns within the same tumor among pulmonary adenocarcinomas and investigate correlations of MUC expression with clinicopathologic features.
Material And Method: We analyzed the expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) in a series of 99 resected lung adenocarcinomas, which included a total of 193 patterns (71 acinar, 30 lepidic, 25 papillary, 20 micropapillary, 34 solid and 13 mucinous) and calculated a final immune reactivity score (FIRS) per tumor.
Objectives: The imaging and surgical literature has confusing association rates for the association between sporadic intracranial cavernous malformations (CMs) and developmental venous anomalies (DVAs). In this study, our purpose was to determine the association rate using ultra-high-resolution C-arm flat-detector CT angiography (FDCTA) and compare it with literature.
Methods: Fifty-eight patients with 60 sporadic intracranial CMs that underwent an FDCTA study were included in our retrospective study.
Article Synopsis
- - This study investigates the role of microsatellite instability (MSI) status and BRAF mutations in predicting outcomes for colorectal cancer patients, analyzing data from 145 cases, focusing on patient survival and clinical characteristics.
- - MMR deficiency was found in 19.3% of patients, with factors like female gender, larger lesion size, and right-sided tumors associated with this deficiency.
- - Higher tumor grade was the only independent predictor of poor survival, while patients with negative BRAF status had better survival rates compared to those with positive BRAF mutations, indicating the need for further research on these biomarkers.