A modified method of planning and delivery for dynamic multileaf collimator intensity-modulated radiation therapy.

Purpose: To develop a modified planning and delivery technique that reduces dose nonuniformity for tomographic delivery of intensity-modulated radiation therapy (IMRT).

Methods And Materials: The NOMOS-CORVUS system delivers IMRT in a tomographic paradigm. This type of delivery is prone to create multiple dose nonuniformity regions at the arc abutment regions.

Role of the endothelium on the response to adrenoceptor agonists of rabbit aorta during cooling.

The role of the endothelium in the effects of cooling on the response to alpha1- and alpha2-adrenoceptor agonists of rabbit aorta was studied. The contractions induced by clonidine (10(-9)-3 x 10(-4) M) and xylazine (10(-7)-10(-3) M) but not phenylephrine (10(-9)-3 x 10(-4) M) and methoxamine (10(-9)-3 x 10(-4) M) were enhanced in endothelium-denuded or N(G)-nitro-L arginine methyl- ester (L-NAME) (10(-5) M) pretreated rabbit aorta. The sensitivity, but not the maximal response, of both alpha1- and alpha2-adrenoceptor agonists was significantly lower at 28 degrees C (cooling) than at 37 degrees C.

A human heterotopic transplant on the beating heart: an interim report of a successful technique performed at Kocaeli University.

Heterotopic heart transplantation is still indicated in selected patients mainly with pulmonary vascular bed problems. Cardio-pulmonary bypass (CPB) has well known deleterious effects on the pulmonary vascular bed due to leukocyte sequestration as well as on the immune response of the patients. Also the negative effects of the cardioplegia on the native heart is another drawback of the classical heterotopic heart transplantation with the use of CPB.

Stasis dermatitis of the hand associated with an iatrogenic arteriovenous fistula.

Stasis dermatitis is a cutaneous finding associated with chronic venous failure resulting in venous stasis. Arteriovenous fistula in the hand may cause a chronic venous stasis. We report a case of stasis dermatitis of the hand associated with an iatrogenic arteriovenous fistula.

Synthesis and antibacterial activities of some new arenesulfonamides and urea derivatives.

Reactions of 3-substituted-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones [I] with some arenesulfonyl chlorides and aryl isocyanates were studied and the corresponding N-(3-substituted-4,5,-dihydro-1H-1,2,4-triazol-5-one-4-yl) arenesulfonamides [II-VI] and N-aryl-N-(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl) ureas [V, VI] were obtained. The structural assignments of new 19 compounds are based on spectral data and elemental analysis. Furthermore, compounds II-VI were tested for their in vitro antimicrobial activities.

[Optimizing a conventional documentation system on the surgical intensive care unit--a contribution to cost reduction and preventive quality management?].

In Intensive Care Units (I.C.U.

Involvement of free radicals in the cardioprotective effect of defibrotide.

Ischemia followed by reperfusion has deleterious effects on myocardial tissue and a wide range of drugs have been investigated to modulate these changes. Defibrotide (polydeoxyribonucleotides from bovine lung), a drug with antithrombotic and fibrinolytic activities, has also proven to be cardioprotective against myocardial ischemia/reperfusion damage. However, the mechanism of this protective effect has not been clarified yet.

Protective effects of cilazapril against free radical injury in myocardial ischaemia-reperfusion.

Cilazapril is a prodrug which is rapidly hydrolysed to the pharmacologically active cilazaprilat following absorption to the bloodstream. In clinical pharmacological studies, administration of cilazapril resulted in potent, reversible, selective and competitive angiotensin converting enzyme inhibition. In this study, we have examined the protective effect of cilazapril on a myocardial ischaemia-reperfusion model by using different parameters of lipid peroxidation and protein oxidation.

A highly stable and selective biosensor using modified nicotinic acetylcholine receptor (nAChR).

Methods for developing stable, sensitive and selective bilayer lipid membrane (BLM)-based biosensors are discussed. Stable BLMs were formed over micromachined polyimide apertures. Selective sensors were made by incorporating nicotinic acetylcholine receptors (nAChRs) modified with bispecific antibodies (BsAbs).

Treatment of congenital venous avalvulosis using a surgically created autogenous vein valve.

A patient with venous valve hypoplasia resulting in chronic venous insufficiency is presented and a method of surgical correction by creation of an autogenous femoral vein valve described. A saphenous vein segment was opened posteriorly and inverted cephalad into the common femoral vein to construct a monocuspid vein valve. At 1 month after operation the patient experienced significant symptomatic improvement.

Fine needle aspiration cytology of oral cavity and jaw bone lesions. A report of 102 cases.

Fine needle aspiration cytology of oral cavity and jaw bone lesions was performed on 102 patients. The cytologic diagnoses were compared with the results of histologic examination. Thirteen of the 15 histologically malignant lesions and 71 of the 87 histologically benign lesions were cytologically diagnosed accurately.

Fine needle aspiration cytologic findings in a benign lymphoepithelial lesion with microcalcifications. A case report.

Aspiration cytologic findings in a case of benign lymphoepithelial lesion (BLL) of the parotid gland are presented. The aspirate contained a polymorphous lymphoid population, histiocytes, myoepithelial and ductal epithelial cells and numerous bluish, calcified bodies. A cytologic diagnosis of benign nonneoplastic lesion, consistent with chronic sialadenitis and microlithiasis, was made.

5-Hydroxytryptamine-induced contraction of human isolated umbilical artery and its dependence on cellular and extracellular Ca++.

The contribution of intra- and extracellular Ca++ during KCl- and 5-hydroxytryptamine-induced contractions was investigated in human isolated umbilical arteries obtained from cords of normal full-term deliveries. In normal solution, nifedipine caused dose-dependent relaxations of the arteries contracted by high K+ (80 mM) and 5-hydroxytryptamine. The IC50 value of nifedipine on KCl-induced contractions was about 9 times lower than that on 5-hydroxytryptamine-induced contractions.

Effects of verapamil, papaverine, sodium nitrite, and hydralazine on ethyl alcohol-induced contraction of the isolated human umbilical artery.

In this in vitro study, the vasodilator effects of certain drugs such as verapamil, papaverine, sodium nitrite and hydralazine on ethyl alcohol-induced contractions were investigated in the isolated human umbilical artery. Ethyl alcohol caused dose dependent contractions in this tissue. Papaverine, sodium nitrite and hydralazine were found to be effective.

Receptor mechanisms for 5-hydroxytryptamine in isolated human umbilical artery and vein.

In order to characterize the 5-hydroxytryptamine (5-HT) receptors, the contractile effects of both 5-HT and alpha-adrenoceptor agonists were studied in helically-cut human umbilical artery and vein in the presence of different antagonists. Noradrenaline, phenylephrine and clonidine caused maximum contractions in vein amounting to only 9%, 14% and 11% of the maximum effect of 5-HT, respectively. The maximum effects of noradrenaline and phenylephrine in artery were only 18% and 29% of that of 5-HT.

Serotonin-induced contraction of canine saphenous vein: mediation by 5-HT1 receptors.

The action of serotonin (5-HT) on alpha 1- and alpha 2-adrenoceptors was investigated on the isolated dog saphenous vein strip. Prazosin (1 X 10(-6) and 1 X 10(-5) M), an alpha 1-adrenoceptor blocker, did not alter 5-HT-induced contractions. However, yohimbine (1 X 10(-6) and 1 X 10(-5) M), an alpha 2-adrenoceptor blocker, shifted the concentration-response curve of 5-HT to the right without any reduction in the maximum response.