Basilar Dolichoarteriopathy and Early Clinical Deterioration in Acute Isolated Pontine Infarction.

Objectives: Early clinical worsening (ECW) in acute isolated pontine infarcts (AIPI) is frequent, associated with poor prognosis, and its predictors have not been adequately clarified. A possible role of dolichoectatic basilar artery (BA) anatomy in ECW in patients with AIPI is herein studied.

Methods: In 146 AIPI patients, infarcts were grouped into tegmental, lateral, anterolateral, anteromedial horizontally; and low, mid, mid-up, and upper pontine vertically.

The relationship between bone health and type of intracranial internal carotid calcifications in patients with ischemic stroke.

Introduction: Vascular calcifications, primarily in the aorta and its proximal branches, are commonly observed among subjects with impaired bone health. In this study, we sought to determine if a comparable association holds true for the calcifications in the intracranial internal carotid arteries (IICA), in general and also for particular calcification patterns.

Methods: A consecutive series of ischemic stroke patients were prospectively enrolled into the study, where computed tomography angiography source images were used to determine the presence and type of IICA calcifications, and dual-energy X-ray absorptiometry was used to determine the bone mineral density in the left femoral neck region.

The Outcome of COVID-19 in Pediatric-Onset Multiple Sclerosis Patients.

Background: The pathogenesis of multiple sclerosis (MS) involves immune-mediated mechanisms, and disease-modifying therapies (DMTs) administered in MS have immunomodulatory effects. The concern about MS patients' susceptibility to coronavirus disease 2019 (COVID-19) has prompted several studies based on clinical observations and questionnaires. Information about COVID-19 in pediatric-onset multiple sclerosis (POMS) is scarce.

Apparent diffusion coefficient signature of ischemic tissue predicts neurological progression in isolated pontine infarcts.

Background: Early neurological deterioration is encountered in up to a third of patients with isolated pontine infarcts. A limited number of clinical and imaging features have been suggested as predictors of neurological progression in this setting. In this study, we assessed whether quantitative apparent diffusion coefficient (ADC) measurements within the ischemic pontine region could be used as a radiomic feature to forecast clinical deterioration.

Intracerebral hemorrhage volume estimation: Is modification of the ABC/2 formula necessary according to the hematoma shape?

Objective: We studied the proposal to modify the ABC/2 formula to ABC/3 for irregular-shaped intracerebral hematoma (ICH) volume estimation.

Patients And Methods: The volume of 133 ICHs were estimated with Kwak's (simplified C; all slices with hemorrhage are considered equal), Kothari's (weighted C) and coronal (reformatted C; measuring C directly on coronal reformatted images) ABC/2 methods, and compared with computer-assisted planimetric measurements. The accuracy, precision and correlation of three ABC/2 methods and their ABC/3 modifications were determined in smooth (Barras' group 1 or 2) and irregular (Barras' group 3-5) shaped ICHs.

Stroke Mechanism in COVID-19 Infection: A Prospective Case-Control Study.

Background: The characteristics and pathophysiological mechanisms involved in acute ischemic stroke in patients with COVID-19 infection have not been fully clarified. We prospectively studied the phenotypic and etiological features of acute stroke occurring in COVID-19 infection.

Patients & Methods: Within nine months starting from April-2020, the presence of COVID-19 infection was determined by thoracic CT and SARS-CoV-2 PCR in all acute stroke cases managed in a single tertiary center.

The dynamics of hematoma surface regularity and hematoma expansion in acute intracerebral hemorrhage.

The clarification of factors that contribute to hematoma expansion in the setting of intracerebral hemorrhage (ICH) and the relevant physical dynamics are implemental for development of management strategies. Herein, we assessed the interplay between hematoma expansion and surface regularity of intracerebral bleeds. To do so, hematoma contours were outlined on admission and follow-up computed tomography (CT) studies using semi-automated thresholding algorithms in 133 ICH patients.