[The features of regulatory T-blood cells subpopulation and the level of CD25 expression in patients with Graves' disease in dynamics after radioactive iodine therapy].

Background: The content of regulatory T cells (Treg) at different stages in formation of effector subpopulations and the level of CD25 expression on the membrane of their various fractions in Graves' disease can determine the long-term autoimmune process persistence and be the target of immunotropic therapy of the disease.

Aim: To study the features of regulatory T-blood cells subpopulation and the level of CD25 expression in patients with Graves' disease in dynamics after radioactive iodine therapy (RIT) to identify the specific Treg subpopulations for potential immunotropic therapy targets of the disease.

Materials And Methods: A single-center, prospective, cohort, open, controlled study was conducted with the participation of women with laboratory-confirmed Graves' disease.

[T-lymphocytes phenotypic composition of peripheral blood in patients with Graves' disease undergoing conservative therapy with thiamazole].

Background: Effective control of autoimmune inflammation in Graves' disease determines necessity to study the T helper (Th) and cytotoxic T-lymphocytes dysfunction, as well as the level of regulatory T-cells (Treg) activation in patients with Graves' disease on thyrostatic medication, which will clarify the immunomodulatory effects of long-term thiamazole treatment serve as targets for more specific therapies.

Aim: To study the phenotypic composition of T-lymphocytes in the peripheral blood of patients with Graves' disease to assess the direction of immune response depending on thimazole-induced euthyroidism duration.

Materials And Methods: A single-center, cohort, continuous, open-label, controlled trial was conducted to assess the phenotypic composition of T-lymphocytes in peripheral blood in women with Graves' disease on long-term thiamazole treatment.

[The activity of NAD- and NAD(P)-dependent dehydrogenases in lymphocytes of peripheral blood in Graves' disease].

Background: The regulatory effect of thyroid hormones on the metabolism of the immune system cells (activation of oxidative processes, separation of oxidative phosphorylation and increased protein synthesis) depends on their number. Changes in the activity of intracellular enzymes in Graves’ disease (GD) can determine the mechanisms of maintaining autoimmune inflammation in relapse of the disease. The exact role of NAD(P)-dependent dehydrogenases in the development and maintenance of immune response in GD is still poorly investigated.

[Impaired visual pathway functions in patients with type 1 diabetes].

The study was undertaken to examine visual pathway function by psycho- and electrophysiological studies in patients with type 1 diabetes. Sixty-three patients (age 25±2.3 years) with moderate type 1 diabetes in a subcompensated state (mean HbA1c 7.

[Clinical and biochemical characteristics of biliferous tract diseases in patients with diabetes mellitus].

The aim of the study was to investigate manifestations of biliferous tract diseases in patients with diabetes mellitus (DM) and to measure concentrations and the ratio of lipids in gall-bladder and liver bile in these patients. 125patients with DM and biliferous tract diseases were examined. Patients with chronic cholecystitis (CC), cholelithiasis, and biliary dyskinesia underwent clinical examination as well as biochemical and instrumental tests.

[Lipid composition of blood serum and bile in biliary diseases in patients with diabetes mellitus].

Aim: To study content and correlation of lipids in the serum and bile from diabetic patients with biliary diseases (BD).

Material And Methods: Serum and bile lipids were studied biochemically in 125 patients with BD and diabetes mellitus and 87 healthy control subjects aged 20-59 years. Serum lipids were studied biochemically as well as content and correlation of duodenal bile lipids.

Prevalence of type 2 diabetes in northern populations of Siberia.

In the first part of the study the prevalence and incidence of diagnosed Type 2 diabetes among adult rural populations of southern, central and northern areas of the Krasnoyarsk region of Siberia is compared. The six-year mean incidence of diabetes in the southern area was 0.86 per 1000 (95% CI: 0.

[Neural network modeling of triiodothyronine concentrations by the levels of lymphocytic NADP-dependent dehydrogenases in patients with thyroid hypo- and hyperfunction].

Whether a computer model which calculates serum triiodothyronine concentrations (T3) can be constructed by the levels of metabolic enzymes in the immunocompetent cells by means of a neural network predictor of real numbers. For this, the concentration of serum T3 and the activity lymphocytic NADP-dependent dehydrogenases were determined by radioimmune assay and bioluminescence technique, respectively. It was found that the neural network prediction might be only in each examined group alone.

[Activity of lymphocyte NAD(P)-dependent dehydrogenase and level of hormones in the blood of healthy people and patients with recurrent acute respiratory diseases].

The activity of NAD(P)-dependent lymphocyte dehydrogenases and their correlation with the blood levels of hormones was studied in healthy individuals and patients with frequently recurrent acute respiratory diseases. There were decreases in the activity of glucose-6-phosphate-, malate-, NAD-dependent glutamate dehydrogenases and direct and reverse reactions catalyzed by lactate dehydrogenase. In the blood of the examinees, the content of the hormones was similar to the physiological values; however, a decrease in content of thyroglobulin and somatotropin was found in the patients with acute respiratory disease.

Goitre prevalence in indigenous population of Evenkia.

Representatives of indigenous northern peoples (the Evenks and the Kets) living in a large Siberian territory named Evenkia were studied. There were children 6-14 years of age and adults aged 18-45 years. Thyroid volumes were determined by ultrasound.