[The quality management in clinical diagnostic laboratory in conditions of the Federal Center of traumatology, orthopedics and endoprosthesis replacement of Minzdrav of Russia (Cheboksary)].

The article presents experience of clinical diagnostic laboratory of the Federal Center of traumatology, orthopedics and endoprosthesis replacement of Minzdrav of Russia (Cheboksary) in the area of quality management of medical laboratory services on the basis of evaluation of efficacy and effectiveness of processes. The factors effecting quality of functioning of clinical diagnostic laboratory are indicated. The criteria and indicators of efficacy of work of employees of clinical diagnostic laboratory are presented.

[Aspects of encephalopathy in oncologic patients after chemotherapy].

Objective: To study clinical presentations and neuroimaging results in post chemotherapy encephalopathy.

Material And Methods: We examined 27 patients with cancer after chemotherapy (n=16) or chemoradiation (n=11).

Results And Conclusion: All patients complained of memory impairment, sluggish mentality, moderate headache, fatigue, sleep disorder, irritability.

[Clinical characteristics and treatment of polyneuropathy developed after chemotherapy].

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the main problem of modern cytotoxic therapy. Drug dose reduction, delay or even complete stopping of chemotherapy until the regression of CIPN symptoms impair treatment effectiveness and patients' survival. We studied 44 cancer patients with CIPN developed after polychemotherapy.

[Optimal doses and timing for tele-irradiation of bone metastases in patients with life expectancy more than 3 months].

The aim of the current study was to improve the bone metastases irradiation parameters in patients with life expectancy more than 3 months. The current randomized study included a total of 333 patients with bone metastases (breast cancer metastases in 71% of cases) receiving 488 courses of photon irradiation. Irradiation effect was observed in 95.

[Age dependence of metabolic syndrome association with obesity types among women].

The study included 335 women aged 21 to 74 years. Results showed that age appears to be associated with progressive accumulation of fat tissue and magnitude of the waist-to-hip circumference ratio, which are mostly expressed in the second period of middle age. Ratio of gynoid and android species frequency among women with overweight and obesity in the first and second period of middle age groups and elderly age was 2.

[Current strategies in radiotherapy for cervical and endometrial carcinoma].

We used combinations of taxan-based neoadjuvant and adjuvant full-dose chemotherapy and aggressive combined radiotherapy including clinical target volume extension, increased total dosage, hyperthermia, cryo- and local chemotherapy as radiosensitizers, for treatment of invasive and locally-advanced breast cancer or endometrial carcinoma with poor prognosis. 3D-ultrasound/CT/MRI--based designing of radiotherapy and monitoring of dynamic definition of target volume and "high risk volume" in organs at risk in cases of tumor progression was an indispensable measure. As a result, no local recurrence was reported in 73% for 36 months.

[Neoadjuvant therapy of breast cancer using Newcastle disease virus].

The role of Newcastle disease virus and neoadjuvant therapy was assessed in 84 cases of breast cancer T1-4N0-2M0 (2005-2008). Combined use of the virus vaccine and chemotherapy (group A), therapy with the vaccine alone (group B) and chemotherapy regimen identical with that used in group A (group C) were compared. Histological pattern of tumor and stage were identified using expression of receptors of steroid hormones, oncoproteins Her2/neu and p53 as well as proliferation activity (marker Ki-67) before and after therapy.

[Certain aspects of neoadjuvant therapy of locally advanced breast cancer].

The paper presents the results of a complex investigation of patients with locally-advanced breast cancer who received neoadjuvant chemotherapy or chemoradiation at initial stage. The clinical and pathomorphological effects, nature of neoadjuvant therapy and number of courses were followed up for 5- and 10-year periods. A direct correlation was found between number of courses for chemotherapy-sensitive patients, on the one hand, and greater effect, more intensive medicinal pathomorphism and longer recurrence-free survival, particularly, at later stages, on the other.

[Structure of bacterial complexes of the river Protva flood-plains].

The synecological analysis of bacterial communities from the Protva River flood-plain biogeocenosis showed that all of the horizons contain spirilla, which are typical hydrobionts, and pigmented coryneform bacteria associated with the herbaceous plants of the flood-plain meadows. The alluvial meadow soils of the inundated regions of the floodplain differed from the unflooded regions of the flood-plain in that they had a more diverse bacterial population continuously distributed over the soil profile.

[Correlation of clinical effect, pathological response of tumor cells and the end results of combined treatment of locally advanced breast cancer].

A correlation was established between the end-results of neoadjuvant chemotherapy for locally-advanced breast cancer and pathological response of tumor cells. Also, the end-results correlated with CR or PR and pathological response. Only a small proportion of patients with tumor progression were registered as stage III or IV of pathological response (0.

[Role of induction chemo- and radiotherapy in the treatment of locally advance breast cancer].

336 patients with locally-advanced breast cancer underwent neoadjuvant chemotherapy or chemoradiotherapy. Increase in T- and N-indices (change of stage after neoadjuvant chemotherapy) proved an important prognostic factor. Survival rates correlated with clinical effect and dropped as it diminished.

[Some prognostic factors in the combined therapy of locally advanced breast cancer].

A relationship between the dynamics of growth and pathological response of tumor cells and the number of neoadjuvant chemotherapy courses was established. As a result, there was no correlation between increase in overall and disease-free survival, on the one hand, and stage, on the other. An interval between neoadjuvant chemotherapy and surgery longer than 4 weeks had a negative effect on overall tumor response and duration of disease-free period.

[Automated radiotherapy in the combined treatment of locally advanced and disseminated ovarian cancer].

The paper deals with the results of treatment of 110 patients with advanced ovarian cancer showing signs of tumor progression following polychemotherapy with two regimens which included radiotherapy. Variants of distant and contact irradiation individually-tailored to suit the types of tumor are discussed. Details of single and repeated courses of chemoradiation are presented.

[Diagnosis and therapy of liver metastasis of breast cancer].

Thirty seven patients received different modalities of chemotherapy for breast cancer disseminated to the liver. Apparent effect was registered in 9 (24.3%) patients (full effect--3 (8.