Role of tumour necrosis factor alpha and CD95 as markers of apoptosis in pathogenesis of pediatrics renal diseases.

Many renal diseases are characterized by mononuclear cell infiltrate, inflammatory cells may provide factors that cause paranchymal cell apoptosis. Monocytes and macrophages release TNFalpha, Fas ligand, oxygen radicle species and nitric oxide which may stimulate or inhibit the inflammatory response. The aim of this work is to investigate the role of apoptosis in pathogenesis of renal diseases.