Synthesis, characterization, and antimicrobial activity of some new N-aryl-N'-(2-oxoindolin-3-ylidene)-benzohydrazonamides.

A green approach was developed for synthesizing a series of (isatin-3-ylidene)-hydrazonamides 3a-j from the reaction between isatin, (isatin-3-ylidene)malononitrile, or 2-cyano-2-(2-isatin-3-ylidene)acetate and benzohydrazonamide in ethyl acetate solutions at ambient temperature. The structures of the new compounds were confirmed on the basis of spectral data. In this eco-friendly medium, a variety of (isatin-3-ylidene)hydrazonamides were obtained free of catalyst in good to excellent yields.