How to Fabricate Hyaluronic Acid for Ocular Drug Delivery.

This review aims to examine existing research on the development of ocular drug delivery devices utilizing hyaluronic acid (HA). Renowned for its exceptional biocompatibility, viscoelastic properties, and ability to enhance drug bioavailability, HA is a naturally occurring biopolymer. The review discussed specific mechanisms by which HA enhances drug delivery, including prolonging drug residence time on ocular surfaces, facilitating controlled drug release, and improving drug penetration through ocular tissues.

Current methods for plastic waste recycling: Challenges and opportunities.

The practical use of plastics has rapidly increased owing to their superior physicochemical properties. Despite their excellent physicochemical properties, the short lifespan of plastics has inevitably led to a substantial generation of plastic waste. As such, strategic mitigation of the hazardous potential of plastic waste has been regarded as significant in waste management.

A practical approach to multifaceted perspectives for sustainable international collaboration on mosquito-borne diseases in Southeast Asia.

The coronavirus disease 2019 pandemic highlighted the necessity and limitations of scientific collaboration and equitable and effective international research partnerships. The spread of mosquito-borne diseases (MBDs) presents severe public health challenges, particularly in Southeast Asia. Addressing these threats requires establishing regional priorities, bridging research gaps, and strengthening long-term international collaboration.

Effect of SiCN thin film interlayer for ZnO-based RRAM.

This study investigates the effect of silicon carbon nitride (SiCN) as an interlayer for ZnO-based resistive random access memory (RRAM). SiCN was deposited using plasma-enhanced chemical vapor deposition with controlled carbon content, achieved by varying the partial pressure of tetramethylsilane (4MS). Our results indicate that increasing the carbon concentration enhances the endurance of RRAM devices but reduces the on/off ratio.

Improved biohydrogen production using Ni/ZrCeO loaded on foam reactor through steam gasification of sewage sludge.

The pervasive generation of sewage sludge (SES) and deficiencies in its disposal methods have resulted in several significant environmental and human health challenges. This study explored the catalytic effect of nickel (Ni)-based CeO, ZrO, Zr.Ce.

Recovery of gaseous fuels through CO-mediated pyrolysis of thermosetting polymer waste.

Thermosetting polymers are used in a wide range of applications due to their robust mechanical strength and superior flame retardancy. Despite these technical benefits, recycling of thermosetting polymers has been challenging because of their crosslinking nature. Moreover, their disposal through conventional methods (landfill and combustion) poses environmental concerns, such as microplastics and air pollutants.

GLP-1 increases preingestive satiation via hypothalamic circuits in mice and humans.

Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) are effective antiobesity drugs. However, the precise central mechanisms of GLP-1RAs remain elusive. We administered GLP-1RAs to patients with obesity and observed a heightened sense of preingestive satiation.

Cdk5 inhibition in the SOD1 transgenic mouse model of amyotrophic lateral sclerosis suppresses neurodegeneration and extends survival.

Deregulated cyclin-dependent kinase 5 (Cdk5) activity closely correlates with hyperphosphorylated tau, a common pathology found in neurodegenerative diseases. Previous postmortem studies had revealed increased Cdk5 immunoreactivity in amyotrophic lateral sclerosis (ALS); hence, we investigated the effects of Cdk5 inhibition on ALS model mice and neurons in this study. For the in vitro study, motor neuron cell lines with wild-type superoxide dismutase 1 (SOD1) or SOD1 and primary neuronal cultures from SOD1 transgenic (TG) mice or non-TG mice were compared for the expression of proteins involved in tau pathology, neuroinflammation, apoptosis, and neuritic outgrowth by applying Cdk5-small interfering RNA or Cdk5-short hairpin RNA (shRNA).

Forensic utility of carboxyhemoglobin levels in postmortem spleen specimens in South Korea.

In order to determine whether CO poisoning was the definitive cause of death, the concentration of carboxyhemoglobin (COHb) in spleen specimens was analyzed using a gas chromatography-thermal conductivity detector. 125 cases of forensic autopsy reports containing COHb analysis requests were analyzed and subdivided into two groups, improbable and highly probable of CO intoxication. In the first group which consists of 100 cases, the results of COHb analysis were negative, and the circumstances of death, as well as the postmortem findings could not validate the exposure to CO.

Oxygen-enriched carbon quantum dots from coffee waste: Extremely active organic photocatalyst for sustainable solar-to-HO conversion.

Solar-driven artificial photosynthesis offers a promising avenue for hydrogen peroxide (HO) generation, an efficient and economical replacement for current methods. The efficiency and selectivity hurdles of the two-electron oxygen reduction reaction (ORR) in solar-to- HO conversion are substantial barriers to large scale production. In this manuscript, a simple biomass-assisted synthesis was performed to produce oxygen-enriched carbon quantum dots (OE-CQDs) from spent coffee waste, acting as an efficient photocatalyst for solar-powered HO production.

Dual effects of TGF-β inhibitor in ALS - inhibit contracture and neurodegeneration.

As persistent elevation of transforming growth factor-β (TGF-β) promotes fibrosis of muscles and joints and accelerates disease progression in amyotrophic lateral sclerosis (ALS), we investigated whether inhibition of TGF-β would be effective against both exacerbations. The effects of TGF-β and its inhibitor on myoblasts and fibroblasts were tested in vitro and confirmed in vivo, and the dual action of a TGF-β inhibitor in ameliorating the pathogenic role of TGF-β in ALS mice was identified. In the peripheral neuromuscular system, fibrosis in the muscles and joint cavities induced by excessive TGF-β causes joint contracture and muscular degeneration, which leads to motor dysfunction.

Strategies for Effective Management of Indoor Air Quality in a Kindergarten: CO and Fine Particulate Matter Concentrations.

The educational and play-related activities of children proceed mainly indoors in a kindergarten. High concentrations of indoor PM and CO have been linked to various harmful effects on children, considerably impacting their educational outcomes in kindergarten. In this study, we explore different scenarios involving the operation of mechanical ventilation systems and air purifiers in kindergartens.

Synthesis of Graphitic Carbon Coated ZnPS and its Superior Electrochemical Properties for Lithium and Sodium Ion Storage.

Graphitic carbon-coated ZnPS is prepared via direct phosphosulfurization and high energy mechanical milling (HEMM) with multiwall carbon nanotubes (MWCNTs) and first introduced as an anode for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs). The HEMM process with MWCNTs reduces the particle size of as-synthesized ZnPS bulk to 100-500 nm and yields the ≈5 nm thick graphitic carbon coated ZnPS nanoparticles, which are the nanocomposites of 5 nm sized nanocrystallites embedded in the amorphous matrix. The ZnPS electrode undergoes the combined conversion and alloying reactions with Li and Na ions and exhibits high initial discharge and charge capacities in both LIBs and SIBs.

Hybrid model for daily streamflow and phosphorus load prediction.

Environmental factors, such as climate change and land use changes, affect water quality drastically. To consider these, various predictive models, both process-based and data-driven, have been used. However, each model has distinct limitations.

Performance enhancement of HfO-based resistive random-access memory devices using ZnO nanoparticles.

In this study, resistive random-access memory (ReRAM) devices with ZnO nanoparticles (NPs) are suggested to enhance performance and reduce variation in device switching parameters. The ZnO NPs are formed by annealing ZnO prepared via atomic layer deposition on HfO, which is verified using transmission electron microscopy, x-ray diffraction pattern, and atomic force microscopy. The depth profile analysis of x-ray photoelectron spectroscopy shows that oxygen diffuses from HfOto ZnO NPs during annealing.

Comprehensive elucidation of the terroir of Korean kimchi through the study of recipes, metabolites, microbiota, and sensory characteristics.

The aim of this study was to investigate the differences in characteristics of the fermented food kimchi based on the regions where it is produced. A total of 108 kimchi samples were collected from five different provinces in Korea to analyze the recipes, metabolites, microbes, and sensory characteristics. Overall, 18 ingredients (including salted anchovy and seaweed), 7 quality indicators (such as salinity and moisture content), 14 genera of microorganisms (mainly Tetragenococcus and Weissella belonging to LAB), and 38 metabolites contributed to the characteristics of kimchi by region.

Metabolites Elicit Anticancer Effects by Inhibiting Autophagy-Related Responses.

() is a probiotic that has emerged as novel therapeutic agents for managing various diseases, such as cancer, atopic dermatitis, inflammatory bowel disease, and infections. In this study, we investigated the potential mechanisms underlying the anticancer effect of the metabolites of . We cultured cells to obtain their metabolites, created several dilutions, and used these solutions to treat human colonic Caco-2 cells.

Synthetic colourants in capsule dietary supplements on the Korean market.

This study developed a rapid and easy analytical method for the simultaneous determination of nine synthetic colourants (SCs) in capsule dietary supplements. Sample pretreatment involved thermal treatment to dissolve gelatin, using the enzymes protease and amylase to prevent the gelation of gelatin and fat-soluble substances removal using petroleum ether. The method was linear ( ≥0.

Large-Scale Screening of the Plant Extracts for Antifungal Activity against the Plant Pathogenic Fungi.

Plants produce chemicals of immense diversity that provide great opportunities for development of new antifungal compounds. In search for environment-friendly alternatives to the fungicide of current use, we screened plant extracts obtained from more than eight hundred plant materials collected in Korea for their antifungal activity against the model plant pathogenic fungus, Magnaporthe oryzae. This initial screening identified antifungal activities from the eleven plant extract samples, among which nine showed reproducibility in the follow-up screening.

Bottom-Gated ZnO TFT Pressure Sensor with 1D Nanorods.

In this study, a bottom-gated ZnO thin film transistor (TFT) pressure sensor with nanorods (NRs) is suggested. The NRs are formed on a planar channel of the TFT by hydrothermal synthesis for the mediators of pressure amplification. The fabricated devices show enhanced sensitivity by 16~20 times better than that of the thin film structure because NRs have a small pressure transmission area and causes more strain in the underlayered piezoelectric channel material.

Production of biochar from crop residues and its application for biofuel production processes - An overview.

A sustainable carbon-neutral society is imperative for future generations, and biochars and biofuels are inevitable choice to achieve this goal. Crop residues (CR) such as sugarcane bagasse, corn stover, and rice husk are promising sustainable resources as a feedstock for biochars and biofuels. Extensive research has been conducted on CR-based biochar production not only in environmental remediation areas but also in application for biofuel production.

Tumor-Suppressive Effect of Metformin via the Regulation of M2 Macrophages and Myeloid-Derived Suppressor Cells in the Tumor Microenvironment of Colorectal Cancer.

Myeloid-derived suppressor cells (MDSCs) and M2 macrophages in the tumor microenvironment contribute to tumor progression by inducing immune tolerance to tumor antigens and cancer cells. Metformin, one of the most common diabetes drugs, has shown anti-inflammatory and anti-tumor effects. However, the effects of metformin on inflammatory cells of the tumor microenvironment and its underlying mechanisms remain unclarified.

Simultaneous feature engineering and interpretation: Forecasting harmful algal blooms using a deep learning approach.

Routine monitoring for harmful algal blooms (HABs) is generally undertaken at low temporal frequency (e.g., weekly to monthly) that is unsuitable for capturing highly dynamic variations in cyanobacteria abundance.