Publications by authors named "DoHyeong Na"
Background: In tauopathies, brain regions with tau accumulation strongly correlate with clinical symptoms, and spreading of misfolded tau along neural network leads to disease progression. However, the underlying mechanisms by which tau proteins enter neurons during pathological propagation remain unclear.
Methods: To identify membrane receptors responsible for neuronal propagation of tau oligomers, we established a cell-based tau uptake assay and screened complementary DNA expression library.
Article Synopsis
- The RAS-BRAF signaling pathway plays a crucial role in cell proliferation, with mutations often linked to various human cancers.
- Adenylate kinase 2 (AK2) has been identified as a BRAF-suppressor, inhibiting BRAF activity and downstream signaling in response to cellular energy states.
- Low levels of AK2 in hepatocellular carcinoma (HCC) patients correlate with increased BRAF activity and tumor growth, suggesting that AK2 serves as a negative regulator of BRAF linked to cellular metabolism.
Mitochondrial quality control maintains mitochondrial function by regulating mitochondrial dynamics and mitophagy. Despite the identification of mitochondrial quality control factors, little is known about the crucial regulators coordinating both mitochondrial fission and mitophagy. Through a cell-based functional screening assay, FK506 binding protein 8 (FKBP8) was identified to target microtubule-associated protein 1 light chain 3 (LC3) to the mitochondria and to change mitochondrial morphology.
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