Publications by authors named "Do-Seon Song"
Introduction And Objectives: The short-term mortality of severe alcoholic hepatitis (SAH) is high, but there are no effective treatments to improve short-term mortality other than corticosteroids. This study investigated the effects of adding rifaximin to standard treatment in patients with SAH.
Material And Methods: In this randomized controlled open-label trial, patients with SAH (Maddrey's discriminant function≥32) were randomized to the rifaximin or control group.
Article Synopsis
- The study explores the relationship between appendicular skeletal muscle mass (ASM) and the severity of metabolic dysfunction-associated steatotic liver disease (MASLD) in patients under 35 years old.
- It found that individuals with MASLD had significantly lower ASM compared to those without MASLD, and that lower ASM was associated with worse liver-related outcomes.
- Increased ASM was linked to a higher likelihood of steatosis regression and lower chances of worsening condition over time, suggesting that ASM plays an important role in the severity of MASLD in younger patients.
Article Synopsis
- A study explored the unclear relationship between diabetes and clinical outcomes in patients with alcoholic liver cirrhosis by analyzing data from 965 patients admitted due to acute decompensation from 2015 to 2019.* -
- Results showed that 23.6% of participants had diabetes, which correlated with increased risks for complications like hepatic encephalopathy and upper gastrointestinal bleeding. Notably, the incidence of death or liver transplantation was higher among diabetic patients.* -
- The findings concluded that diabetes significantly increases the risk of death or liver transplantation in these patients, leading to poorer health outcomes over time.*
Article Synopsis
- The study aimed to evaluate the effectiveness and tolerability of direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV) across different genotypes (GTs) in a global, real-world context, focusing particularly on GT3 and GT6.
- Researchers analyzed data from 15,849 chronic hepatitis C patients across Asia, North America, and Europe over a seven-year period, noting demographic factors such as age, sex, and prior treatment history.
- Results showed a high sustained virological response (SVR12) rate of 96.9% overall, with variances by genotype, highlighting that independent factors like advanced age, cirrhosis, and previous treatment failures affected treatment outcomes, while being
Background: It is unclear whether direct-acting antivirals (DAAs) treatment improves the disease burden in hepatitis C virus (HCV) infection. This study aimed to investigate the effect of DAA treatment on the reduction of disease burden in patients with HCV infection using individual participant data.
Methods: This nationwide multicentre retrospective cohort study recruited patients with HCV infection from 29 tertiary institutions in South Korea.
Article Synopsis
- Childhood obesity is linked to a rising prevalence of nonalcoholic fatty liver disease (NAFLD) in kids and teens, yet systematic studies on this issue are scarce.
- A comprehensive search of multiple databases yielded 62 relevant studies for analysis, revealing that NAFLD affects 13% of the general pediatric population and 47% of obese kids.
- The study found significant gender differences in prevalence, with higher rates in males than females for both general and obese populations, highlighting the urgent need for more epidemiological research on NAFLD in pediatrics.
Validation of MELD 3.0 in patients with alcoholic liver cirrhosis using prospective KACLiF cohort.
J Gastroenterol Hepatol
September 2024
Background And Aim: The Model for End-Stage Liver Disease (MELD) is a reliable prognostic tool for short-term outcome prediction in patients with end-stage liver disease. MELD 3.0 was introduced to enhance the predictive accuracy.
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- The study evaluated a modified version of the quick sequential organ failure assessment (m-qSOFA) to identify high-risk patients with deteriorating chronic liver disease, particularly those with acute-on-chronic liver failure.
- Patients with a high m-qSOFA score had significantly lower transplant-free survival rates and higher organ failure development compared to those with low scores across two different cohorts.
- The findings suggest that both initial m-qSOFA scores and changes over time can help predict the risk of organ failure and short-term mortality in patients with acute deterioration of liver disease.
Background/aims: Drugs that stabilize intestinal motility may improve the efficacy of nonabsorbable antibiotics, such as rifaximin, against small intestinal bacterial overgrowth (SIBO). We compared the efficacy of rifaximin alone with that of its combination with trimebutine maleate against SIBO.
Methods: We performed a randomized double-blind placebo-controlled trial (https://cris.
Background: Atezolizumab+bevacizumab (AB) and lenvatinib have been proposed as first-line treatment options for patients with advanced hepatocellular carcinoma (HCC), but comparative efficacy and associated factors are controversial.
Materials And Methods: This real-world multicenter study analysed patients with HCC who received AB (n=169) or lenvatinib (n=177).
Results: First, 1:1 propensity score matching (PSM) was performed, resulting in 141 patients in both the AB and lenvatinib groups.
Article Synopsis
- The study focuses on the prognosis of cirrhotic patients following their first acute decompensation (AD) episode, categorizing outcomes into four groups: stable decompensated cirrhosis (SDC), unstable decompensated cirrhosis (UDC), pre acute-on-chronic liver failure (pre ACLF), and ACLF.
- The research involved a cohort of 746 patients and identified risk factors for readmission after AD, revealing that pre ACLF has a worse prognosis than ACLF despite occurring later.
- Factors such as non-variceal gastrointestinal bleeding and hepatic encephalopathy significantly increase readmission risk, with viral causes linked to poorer outcomes compared to alcohol-related cases.
Background & Aims: Few studies have investigated the prognosis of patients with non-severe alcoholic hepatitis (Non-SAH). The study aimed to develop a new prognostic model for patients with especially Non-SAH.
Methods: We extracted 316 hospitalized patients with alcoholic cirrhosis without severe alcoholic hepatitis, defined as Maddrey's discriminant function score lower than 32, from the retrospective Korean Acute-on-Chronic Liver Failure (KACLiF) cohort to develop a new prognostic model (training set), and validated it in 419 patients from the prospective KACLiF cohort (validation set).
Risk of Hepatitis C Virus Transmission through Acupuncture: A Systematic Review and Meta-Analysis.
Korean J Gastroenterol
September 2023
Background/aims: Chronic hepatitis C is a major risk factor for liver cirrhosis, hepatocellular carcinoma, and hepatic failure. Although traditional practices, including acupuncture, tend to increase the risk of HCV infection, the association remains controversial. Therefore, the current meta-analytical study was undertaken to evaluate the risks of acupuncture and hepatitis C transmission.
View Article and Find Full Text PDFThis study aimed to compare the treatment outcomes of atezolizumab-plus-bevacizumab (Ate/Bev) therapy with those of transarterial chemoembolization plus radiotherapy (TACE + RT) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) and without metastasis. Between June 2016 and October 2022, we consecutively enrolled 855 HCC patients with PVTT. After excluding 758 patients, 97 patients (n = 37 in the Ate/Bev group; n = 60 in the TACE + RT group) were analyzed.
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- The study examines the effectiveness of abdominal ultrasonography (USG) as a screening tool for hepatocellular carcinoma (HCC) in high-risk groups in South Korea.
- Data was gathered from 8,512 USG examinations conducted by experienced hepatologists and radiologists in 2017, showing a very low HCC detection rate of only 0.3%.
- Findings suggest that patient-related factors like age and liver condition significantly impact HCC detection rates, highlighting the need for improved quality measures in USG procedures.
Article Synopsis
- New biomarkers are needed for early diagnosis of hepatocellular carcinoma (HCC), and this study focuses on circulating tumor DNA (ctDNA) in patients with hepatitis B virus-induced HCC.
- The meta-analysis included nine studies with 2,161 participants and found that ctDNA has a sensitivity of 70.5% and specificity of 83.3%, indicating its potential in diagnostics.
- Results suggest that ctDNA, especially when combined with traditional tumor markers, can enhance screening and detection of HCC.
The association between nonalcoholic fatty liver disease (NAFLD) and sarcopenia is known. We aimed to determine the association between skeletal muscle mass changes and NAFLD status. This retrospective single-center study analyzed patients who underwent health screening twice between November 2009 and December 2017, with a temporal gap of 6 ± 0.
View Article and Find Full Text PDFBackground: The global burden of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing.
Aims: This study aimed to evaluate the effect of exercise on intrahepatic lipid (IHL), serum alanine aminotransferase (ALT), body mass index (BMI), and insulin resistance in NAFLD patients.
Methods: We searched MEDLINE, Embase, Cochrane CENTRAL, KMbase, and the Korean Studies Information Service System through April 2022.
Background/aims: To evaluate the effectiveness and safety of direct acting antivirals (DAAs) available in chronic kidney disease (CKD) patients with hepatitis C virus (HCV) infection in Korea.
Methods: In a retrospective, multicenter cohort study, 362 patients were enrolled from 2015 to 2019. The effectiveness and safety of DAAs including glecaprevir/pibrentasvir, sofosubvir/ribavirin, ledipasvir/sofosbuvir, and daclatasvir/asunaprevir were analyzed for patients according to CKD stage.