Publications by authors named "Do-Kuk Kim"
The present study was undertaken to investigate the anti‑obesity effect of a 50% ethanol extract of Euphorbia supina (ESEE) in high‑fat‑diet (HFD)‑induced obese C57BL/6J mice. Mice were fed a HFD with or without ESEE (2, 10, or 50 mg/kg) or with Garcinia cambogia (positive control) for 6 weeks. ESEE supplementation significantly reduced body, epididymal white adipose tissue (eWAT), and organ weights (P<0.
View Article and Find Full Text PDFAnti-inflammatory effect of Euphorbia supina extract in dextran sulfate sodium-induced colitis mice.
Biosci Biotechnol Biochem
November 2017
Article Synopsis
- The study investigates the anti-inflammatory properties of Euphorbia supina (ES) ethanol extract on colitis induced by dextran sulfate sodium (DSS).
- Administering 20 mg/kg of ES significantly mitigates symptoms such as weight loss and colon shortening, while also improving disease activity scores and enzyme levels.
- Histological analysis reveals that ES reduces tissue damage and inflammation markers in the colon, suggesting its potential for treating ulcerative colitis.
The present study investigated the role of extracellular signal-regulated kinase (ERK) activation in the migratory phenotype of human U2OS osteosarcoma (OS) cells in a collagen matrix. The activation of ERK was inhibited by PD98059, a specific inhibitor of ERK kinase. Additionally, no significant differences were observed in the adhesion and proliferation of the cells with or without PD98059 treatment in collagen-coated dishes.
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