Publications by authors named "Do Vo Anh Khoa"
Article Synopsis
- Ungulate protoparvovirus 1 (PPV1) is a leading cause of reproductive issues in pig farms, with several other related parvoviruses (PPV2, PPV3, PPV4) also identified but less studied in pigs.
- A study tested 231 lung and serum samples from slaughterhouses in Vietnam, finding a prevalence of 54.5% for PPV1, 28.0% for PPV2, 17.7% for PPV3, and 7.8% for PPV4, with co-infections primarily involving PPV1 and PPV2.
- The research documented nearly complete genomic sequences of PPV4, revealing high genetic similarity
Article Synopsis
- PRRSV is a significant swine virus in Vietnam causing economic losses by reducing pig productivity, and this study analyzed 32 PRRSV isolates collected from 2008-2012.
- The sequencing of the major envelope protein encoding gene (ORF5) revealed high genetic similarity among the isolates (94.8-100% nucleotide identity), particularly with North American and some Chinese strains.
- Phylogenetic analysis classified the isolates into the North American genotype, specifically sub-lineage 8.7, which includes highly pathogenic strains, indicating the need for updated PRRS vaccine strategies in Vietnam.
Background: The complement system is an evolutionary ancient mechanism that plays an essential role in innate immunity and contributes to the acquired immune response. Three modes of activation, known as classical, alternative and lectin pathway, lead to the initiation of a common terminal lytic pathway. The terminal complement components (TCCs: C6, C7, C8A, C8B, and C9) are encoded by the genes C6, C7, C8A, C8B, C8G, and C9.
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