A new benzophenanthridine alkaloid from stem bark of and its biological activities.

A new benzophenanthridine alkaloid 6-butanoyldihydrochelerythrine and five known alkaloids 6-acetonyldihydronitidine , 6-acetonyldihydrochelerythrine , isocorydine , (O)-methyltembamide , N-(4-methoxyphenethyl)benzamide were isolated from the stem barks of . These structures were elucidated by 1D, 2D NMR spectroscopy and by mass spectrometry. This is the first time that compounds were identified from and the first time that compounds and were identified from the genus .

Natural Phosphodiesterase-4 Inhibitors with Potential -Inflammatory Activities from .

The results of in silico screening of the 50 isolated compounds from against the target proteins PDE4 (PDE4A, PDE4B, and PDE4D) showed binding affinity ranges from -5.81 to -11.56, -5.

Chemical Composition and Biological Activities of Essential Oils of Four Species Growing in Vietnam.

The essential oils (EOs) of the aerial parts of four species (, , and were isolated by steam distillation and analyzed by the GC/MS method. The EO contains 33 constituents with the main component being elemicine (77.20%).

Hepatoprotective Effect of : In Vitro and In Silico Study.

In silico docking studies of 50 selected compounds from Harms ex Diels (family Leguminosae) were docked into the binding pocket of the PI3K/mTOR protein. In there, compounds -3--hydroxycinnamoyl ursolic acid () and 5,7,4'-trihydroxyisoflavone 7---D-apiofuranosyl-(1→6)--D-glucopyranoside () are predicted to be very promising inhibitors against PI3K/mTOR. They direct their cytotoxic activity against with binding affinity (BA) values, the pulling work spent to the co-crystallized ligand from the binding site of PI3K/mTOR (W and F), and the non-equilibrium binding free energy (∆G) as BA values = -9.

Two new terpenoids from the leaves of .

Two new terpenoids (-) and seven known compounds (-) were isolated from methanol extract of leaves. Their structures were determined to be -7,16,17,18-tetrahydroxykaur-15-one (), 3-acetoxy-urs-12-ene-11-one-12-ol (), -1-acetoxy-7,14-dihydroxykaur-16-en-15-one (), 3-acetoxy-11,13-dihydroxyolean-12-one (), -amyrin (), spinasterol (), ursolic acid (), -sitosterol (), and daucosterol () by analyses of their MS, NMR spectroscopic data and by comparison with those reported in the literature. Compounds - , and displayed potential cytotoxic activity towards HepG-2, LU-1, and MCF-7 human cancer cell lines with IC values ranging from 0.

Fatty Acid, Lipid Classes and Phospholipid Molecular Species Composition of the Marine Clam (Sowerby 1851) from Cua Lo Beach, Nghe An Province, Vietnam.

This study aims to analyze compositions of fatty acids and phospholipid molecular species in the hard clams (Sowerby, 1851) harvested from Cua Lo beach, Nghe An province, Viet Nam. Total lipid of hard clams occupied 1.7 ± 0.

New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities.

One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2-5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines.