Publications by authors named "Do Thien Hai"
Severe Neurological Complications With Influenza in Vietnamese Children.
Influenza Other Respir Viruses
November 2024
Background: Influenza is a common contagious respiratory virus that primarily causes respiratory tract infections. Neurological complications associated with influenza have also been reported, mainly in pediatric populations, and may be fatal.
Methods: A descriptive study evaluated pediatric patients who were diagnosed with severe influenza-associated neurological complications at the Tropical Pediatrics Center-Vietnam National Children's Hospital from October 2022 to February 2024.
An advisory board meeting was held with experts in Vietnam (Hanoi, August 2022), to review the evidence on invasive meningococcal disease (IMD) epidemiology, clinical management, and meningococcal vaccines to reach a consensus on recommendations for meningococcal vaccination in Vietnam. IMD is a severe disease, with the highest burden in infants and children. IMD presents as meningitis and/or meningococcemia and can progress extremely rapidly.
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- Echovirus 30 (E30) and Japanese encephalitis virus (JEV) are prevalent causes of acute meningitis in Southeast Asia, prompting a study to differentiate between them due to potential misdiagnosis, particularly during an outbreak in Vietnam (2001-2002).
- A retrospective study analyzed clinical records of 43 E30 and 60 JEV cases, comparing symptoms and clinical parameters using statistical methods.
- Results indicated that symptoms like fever, headache, and vomiting were common to both, but E30 cases showed a higher prevalence of headache and vomiting combinations, while JEV cases exhibited stronger neurological symptoms and distinct cerebrospinal fluid (CSF) profiles.