Publications by authors named "Do Thanh Tuan"
L. (Solanaceae) has been used in tropical and subtropical countries of the world as medicinal and fruit trees. In this study, a new withanolide named withaperuvin O () and seven known ones, including physalolactone B-3-O--D-glucopyranoside (), withanolide J (), physapruin A (), physaperuvin G (), withaperuvin (), withaperuvin C () and 28-hydroxywithaperuvin C (), were isolated from the whole plants of .
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- A study on a specific plant variety identified seven alkaloids, including a new compound called bis-(-)-8-demethylmaritidine, using advanced techniques like NMR and HR-ESI-MS.
- One alkaloid showed the strongest ability to inhibit acetylcholinesterase (AChE), suggesting its potential as a treatment for Alzheimer's disease through further molecular analysis.
Article Synopsis
- A phytochemical study on the methanol extract of stems and leaves led to the discovery of six dibenzocyclooctadiene lignans, including three new compounds named kadsindutalignans A, B, and C.
- Their structures were identified through various spectroscopic techniques like HRESIMS and NMR, which provided detailed insights into their molecular configurations.
- All isolated compounds demonstrated the ability to inhibit NO production in LPS-activated RAW264.7 cells, with the new compound showing particularly strong activity, surpassing the effectiveness of the positive control (L-NMMA).
Two new phenolic glycosides, physangulosides A and B (1 and 2), were isolated from the whole plant of Physalis angulata. Their chemical structures were determined by mean of HR-ESI-MS, lD, and 2D-NMR spectra. Both of the compounds showed weak protection against hydrogen peroxide induced hepatocytes damage.
View Article and Find Full Text PDFInhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.
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