Publications by authors named "Do Lee"

Hydrogen-bond-driven 1D assembly of carbon nanotubes dispersed in organic solvents remains challenging owing to difficulties associated with achieving high oxidation levels and uniform dispersion. Here, we introduced a bioinspired wet-spinning method that utilizes highly oxidized single-walled carbon nanotubes dispersed in organic solvents without superacid or dispersants. By incorporating submicrometer-sized graphene oxide nanosheets, we facilitated the ejection of 1.

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The conventional carbonization process for synthesizing hard carbons (HCs) requires high-temperature furnace operations exceeding 1000 °C, leading to excessive energy consumption and lengthy processing times, which necessitates the exploration of more efficient synthesis methods. This study demonstrates the rapid preparation of HC anodes using intense pulsed light (IPL)-assisted photothermal carbonization without the prolonged and complex operations typical of traditional carbonization methods. A composite film of microcrystalline cellulose (MCC) and single-walled carbon nanotubes (SWCNTs) is carbonized at high temperatures in less than 1 min.

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Introduction: Prosthetic joint infection (PJI) is one of the most common and detrimental complications of total knee replacement arthroplasty (TKA). Despite extensive efforts, including two-stage reimplantation, to eradicate PJI, it still recurs in a substantial number of patients. However, the risk factors of recurrence after two-stage reimplantation of the knee have not been established.

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Hepatic metabolism is an important process for evaluate the potential activity and toxicity of endocrine disrupting chemicals (EDCs) metabolites. Organization for Economic Co-operation and Development (OECD) has advocated the development of in vitro assays that mimic in vivo hepatic metabolism to eventually replace classical animal tests. In response to this need, we established a 3D mouse liver organoid (mLO) platform that mimics the animal model and is distinct from existing models.

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Members of the Anopheles Hyrcanus Group, Culex pipiens complex, and Culex tritaeniorhynchus are prevalent vector species in the Republic of Korea (ROK), transmitting Plasmodium vivax and various arboviruses. Extensive use of insecticides to control these mosquitoes has led to insecticide resistance. In this study, we monitored 3 target site mutations associated with insecticide resistance (kdr for pyrethroid resistance, ace1 for organophosphate resistance, and rdl for phenylpyrazole resistance) in these mosquito groups over four consecutive years to understand the seasonal dynamics of resistance in different areas with distinct ecological characteristics.

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  • Recent advancements in nanomedicine have shown that exosome-based therapies could be effective for targeted cancer treatment, particularly in colon cancer.
  • A study explored the effectiveness of siPIN1-loaded exosomes that target a specific ligand (sAPRIL) in cancer models, demonstrating that these engineered exosomes have enhanced anticancer properties.
  • Results indicated that the tEx[p] group, which had the siPIN1 RNA loaded, significantly reduced tumor size and growth compared to other treatments, suggesting a promising new strategy for colon cancer therapy.
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Having osteoarthritis in one knee is reported as an independent risk factor for developing contralateral knee osteoarthritis (KOA). However, no study has been designed to predict the development of contralateral KOA (cKOA). The authors hypothesized that specific risk factors for cKOA development exist and that it could be accurately predicted with the assistance of machine learning.

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Laser-induced graphene (LIG) has attracted considerable attention for its use in flexible and stretchable sensors, owing to its electrical/mechanical properties and scalable fabrication processes. Although laser scanning facilitates the formation of LIG and its strain sensor, the strain-sensing sensitivity enhancement of LIG remains limited by the material's properties and structural design. In this study, we demonstrate a substantial improvement in sensitivity that was achieved by fabricating a LIG using ZnO nanoparticle (NP)-assisted photothermal enhancement.

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Edible insects are gaining attention as potential nutraceutical sources with immunomodulatory properties. This study reports purification and structural characterization of polysaccharides from Protaetia brevitarsis seulensis larvae (PBSL) with antiviral activity against murine norovirus. Four polysaccharide fractions purified from PBSL water extracts exhibited varying molecular weights (458.

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Importance: Recent articles have highlighted the existence of pelvic floor myofascial dysfunction in women presenting with pelvic floor disorders.

Objective: The aim of the study was to evaluate whether younger age is associated with pelvic floor muscle dysfunction in women with lower urinary tract symptoms, including urinary urgency, frequency, nocturia, and urinary incontinence.

Study Design: This retrospective cohort study included women seeking an initial outpatient urogynecology evaluation for urinary symptoms from 8/2018 to 2/2022.

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Cancer causes over 10 million deaths annually worldwide and remains a significant global health challenge. This study investigated advanced immunotherapy strategies, focusing on mRNA vaccines that target tumor-specific antigens to activate the immune system. We developed a novel mRNA vaccine using O,O'-dimyristyl-N-lysyl aspartate (DMKD) to improve stability and phosphatidylserine (PS) to enhance antigen presentation to immune cells.

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Background: The Anopheles Hyrcanus group, which transmits Plasmodium vivax, consists of six confirmed species in South Korea. An epidemiological study revealed differences in the seasonal occurrence patterns of each species. Pyrethroid resistance in An.

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Many models using the aid of artificial intelligence have been recently proposed to predict the progression of knee osteoarthritis. However, previous models have not been properly validated with an external data set or have reported poor predictive performances. Therefore, the purpose of this study was to design a machine learning model for knee osteoarthritis progression, focusing on high validation quality and clinical applicability.

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Background: Insomnia is a prevalent disorder that impacts quality of life and leads to significant economic costs. Treatment includes both non-medication and pharmacological interventions, with international guidelines recommending cognitive behavioral therapy for insomnia (CBT-I) as the first-line treatment.

Objective: To describe current insomnia treatment practices in South Korea, focusing on pharmacological and non-medication treatments, and to identify gaps in guideline implementation.

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  • * Research shows that USF2, in conjunction with HDAC1, represses lysosomal and autophagy genes when nutrients are abundant by altering histone modifications and chromatin structure.
  • * Under starvation, USF2 competes with TFEB to control gene expression related to lysosomes, and findings suggest that targeting USF2 could be beneficial for treating diseases linked to protein aggregation, like α1-antitrypsin deficiency.
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  • Anaplerosis is when certain enzymes help replace important molecules in a cycle that produces energy in cells.
  • The enzyme pyruvate carboxylase (PYC) is important for this process and helps create a molecule called oxaloacetate.
  • Researchers found that deleting the PYC1 gene in two types of fungi had different effects; for one type, it hurt its growth and ability to cause disease, while the other type was mostly unaffected.
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Sleep is one of the most essential physiological phenomena for maintaining health. Sleep disturbances, such as insomnia, are often accompanied by psychiatric or physical conditions such as impaired attention, anxiety, and stress. Medication used to treat insomnia have concerns about potential side effects with long-term use, so interest in the use of alternative medicine is increasing.

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Background: Fine-grained classification deals with data with a large degree of similarity, such as cat or bird species, and similarly, knee osteoarthritis severity classification [Kellgren-Lawrence (KL) grading] is one such fine-grained classification task. Recently, a plug-in module (PIM) that can be integrated into convolutional neural-network-based or transformer-based networks has been shown to provide strong discriminative regions for fine-grained classification, with results that outperformed the previous deep learning models. PIM utilizes each pixel of an image as an independent feature and can subsequently better classify images with minor differences.

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  • * Researchers discovered that ARID1A, a protein linked to cancer, contains a prion-like domain that facilitates LLPS, particularly evident in Ewing's sarcoma patient samples.
  • * Disruption of ARID1A's LLPS impairs cancer cell growth and invasion, suggesting that targeting this mechanism could offer new treatment strategies for Ewing's sarcoma.
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Neuropathic pain (NP) results from lesions or diseases affecting the peripheral or central somatosensory system. However, there are currently no drugs that are particularly effective in treating this condition. SKI306X is a blend of purified extracts of three oriental herbs (Clematis mandshurica, Trichosanthes kirilowii, and Prunella vulgaris) commonly used to treat osteoarthritis for their chondroprotective effects.

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