Serum Level of Cadherin-P (CDH3) Is a Novel Predictor of Cardiovascular Events Related to Atherosclerosis in a 3-Year Follow-Up Study.

: Placental cadherin (CDH3) is an adhesion molecule expressed in many malignant tumors. The role of serum CDH3 in atherosclerosis is unclear. : This 3-year follow-up study measured atherosclerosis and serum CDH3 in 218 angiography inpatients.

Thermoresponsive carboplatin-releasing prodrugs.

Platinum-based anticancer drugs, while potent, are associated with numerous and severe side effects. Hyperthermia therapy is an effective adjuvant in anticancer treatment, however, clinically used platinum drugs have not been optimised for combination with hyperthermia. The derivatisation of existing anticancer drugs with appropriately chosen thermoresponsive moieties results in drugs being activated only at the heated site.

Observation of time-reversal symmetry breaking in the band structure of altermagnetic RuO.

Altermagnets are an emerging elementary class of collinear magnets. Unlike ferromagnets, their distinct crystal symmetries inhibit magnetization while, unlike antiferromagnets, they promote strong spin polarization in the band structure. The corresponding unconventional mechanism of time-reversal symmetry breaking without magnetization in the electronic spectra has been regarded as a primary signature of altermagnetism but has not been experimentally visualized to date.

Thermal expansion anisotropy of FeMo and FeMo μ-phases predicted using first-principles calculations.

The intermetallic μ-phase, which precipitates in steels and superalloys, can noticeably soften the mechanical properties of their matrix. Despite the importance of developing superalloys and steels, the thermodynamic properties and directions of thermal expansion of the μ-phase are still poorly studied. In this work, the thermal expansion paths, elastic, thermal and thermodynamic properties of the FeMo and FeMo μ-phases are studied using the first-principles-based quasi-harmonic Debye-Grüneisen approach.

Influence of Bi doping on the electronic structure of (Ga,Mn)As epitaxial layers.

The influence of the addition of Bi to the dilute ferromagnetic semiconductor (Ga,Mn)As on its electronic structure as well as on its magnetic and structural properties has been studied. Epitaxial (Ga,Mn)(Bi,As) layers of high structural perfection have been grown using low-temperature molecular-beam epitaxy. Post-growth annealing of the samples improves their structural and magnetic properties and increases the hole concentration in the layers.

Application of an antibody microarray for serum protein profiling of coronary artery stenosis.

Protein expression profiling in the serum is used to identify novel biomarkers and investigate the signaling pathways in various diseases. The aim of the present study was to evaluate serum biomarkers associated with coronary artery stenosis resulting from atherosclerosis. The study included 4 groups of subjects: group A and B with and without coronary lesions, respectively, were selected from a previously reported cohort study on coronary atherosclerosis, control group C comprised of asymptomatic subjects and group D was used for independent validation of the microarray data by ELISA.

CO Electroreduction on Silver Foams Modified by Ionic Liquids with Different Cation Side Chain Length.

Ionic liquids (ILs) are capable of tuning the kinetics of electroreduction processes by modifying a catalyst interface. In this work, a group of hydrophobic imidazolium-based ILs were immobilized on Ag foams by using a procedure known as "solid catalyst with ionic liquid layer" (SCILL). The derived electrocatalysts demonstrated altered selectivity and CO production rates for the electrochemical reduction of CO compared to the unmodified Ag foam.

DETECTION OF IN THREE FILE SNAKES () IMPORTED FROM INDONESIA TO THE MOSCOW ZOO (RUSSIA).

Three file snakes () were delivered to the Moscow Zoo (Russia) from Jakarta (Indonesia). Shortly after arrival, multiple white blisters were detected on their bodies. All three snakes died within a month of arrival.

Electroreductive 5-Hydroxymethylfurfural Dimerization on Carbon Electrodes.

The electrochemical conversion of biomass-based compounds to fuels and fuel precursors can aid the defossilization of the transportation sector. Herein, the electrohydrodimerization of 5-hydroxymethylfurfural (HMF) to the fuel precursor 5,5'-bis(hydroxymethyl)hydrofuroin (BHH) was investigated on different carbon electrodes. Compared to boron-doped diamond (BDD) electrodes, on glassy carbon (GC) electrodes a less negative HMF reduction onset potential and a switch in product selectivity from BHH to the electrocatalytic hydrogenation product 2,5-di(hydroxymethyl)furan (DHMF) with increasing overpotential was found.

Subpicosecond metamagnetic phase transition in FeRh driven by non-equilibrium electron dynamics.

Femtosecond light-induced phase transitions between different macroscopic orders provide the possibility to tune the functional properties of condensed matter on ultrafast timescales. In first-order phase transitions, transient non-equilibrium phases and inherent phase coexistence often preclude non-ambiguous detection of transition precursors and their temporal onset. Here, we present a study combining time-resolved photoelectron spectroscopy and ab-initio electron dynamics calculations elucidating the transient subpicosecond processes governing the photoinduced generation of ferromagnetic order in antiferromagnetic FeRh.

Development and Research of a Theoretical Model of the Magnetic Tunnel Junction.

Spin-dependent tunneling structures are widely used in many spintronic devices and sensors. This paper describes the magnetic tunnel junction (MTJ) characteristics caused by the inhomogeneous magnetic field of ferromagnetic layers. The extremely oblate magnetic ellipsoids have been used to mimic these layers.

MiRNA let-7 from TPO(+) Extracellular Vesicles is a Potential Marker for a Differential Diagnosis of Follicular Thyroid Nodules.

Background: The current approaches to distinguish follicular adenomas (FA) and follicular thyroid cancer (FTC) at the pre-operative stage have low predictive value. Liquid biopsy-based analysis of circulating extracellular vesicles (EVs) presents a promising diagnostic method. However, the extreme heterogeneity of plasma EV population hampers the development of new diagnostic tests.

Relation between spin-orbit induced spin polarization, Fano-effect and circular dichroism in soft x-ray photoemission.

A Feynman diagram analysis of photoemission probabilities suggests a relation between two final-state spin polarization effects, the optical spin-orientation originating from the interaction with circularly polarized light ([Formula: see text], Fano effect) and the spin polarization induced by the spin-orbit scattering ([Formula: see text], Mott effect). The analysis predicts that [Formula: see text] is proportional to the product of [Formula: see text] and the circular dichroism in the angular distribution (CDAD) of photoelectrons. To confirm this prediction, the spin polarization of photoelectrons excited by soft x-ray radiation from initial spin-degenerate bulk states of tungsten using time-of-flight momentum microscopy with parallel spin detection has been measured.

Delineation of the Critical Parameters of Salt Catalysts in the N-Formylation of Amines with CO.

N-formylation of amines combining CO as a C1 source with a hydrosilane reducing agent is a convenient route for the synthesis of N-formylated compounds. A large number of salts including ionic liquids (ILs) have been shown to efficiently catalyze the reaction and, yet, the key features of the catalyst remain unclear and the best salt catalysts for the reaction remain unknown. Here we demonstrate the detrimental effect of ion pairing on the catalytic activity and illustrate ways in which the strength of the interaction between the ions can be reduced to enhance interactions and, hence, reactivity with the substrates.

Endocrinology of obese and nonobese endometrial cancer patients: is there role of tumor molecular-biological type?

To compare endocrine characteristics of  endometrial cancer (EC) patients based on recent molecular EC types classification.  A total of 234 treatment-naive EC patients as well their tumors were studied. Patients with mutations demonstrated tendency to lower body mass index (BMI) and higher serum estradiol.

A General and Facile Approach for the Electrochemical Reduction of Carbon Dioxide Inspired by Deep Eutectic Solvents.

Deep eutectic solvents (DESs) were applied to the electrochemical CO reduction reaction (CO RR). Choline-based DESs represent a non-toxic and inexpensive alternative to room-temperature ionic liquids (RTILs) as additives to the system or as electrolyte. Following the study on choline-based DESs this approach was generalized and simple and organic-soluble systems were devised based on the combination of organic chloride salts with ethylene glycol (EG), allowing the chlorides to be readily used as cocatalysts in the CO RR.

Unpredictable cycloisomerization of 1,11-dien-6-ynes by a common cobalt catalyst.

1,11-Dien-6-ynes undergo cycloisomerization in the presence of the cobalt catalytic system CoBr/phosphine ligand/Zn/ZnI giving cyclohexene, diene or cyclopropane structures depending on the type of the phosphine ligand. This unpredictable behaviour suggests that, although the availability of the cobalt catalytic system is appealing, the development of well-defined catalysts is desirable for further progress.

Features of endometrial cancer in patients with 'metabolically healthy' versus 'standard' obesity: the decreasing frequency of metabolically healthy obesity.

Background: As endometrial cancer (EC) prevalence increases with obesity, we aimed to determine whether EC characteristics depend upon obesity type: 'standard' (SO) or 'metabolically healthy obesity' (MHO).

Patients & Methods: 258 EC patients were included. Data on anthropometry, blood hormones, lipids and glucose, and tumor features were collected.

Features of omental adipose tissue in endometrial cancer patients with 'standard' or 'metabolically healthy' obesity: associations with tumor process characteristics.

Purpose: Adipose tissue products may contribute to endometrial cancer (EC) initiation and further growth that encourages the analysis of this issue in patients with different obesity phenotypes.

Methods/patients: Omental fat depot characteristics were studied in EC patients (n = 57) with "standard" (SO) or "metabolically healthy" (MHO) obesity. Collected omental samples were evaluated by immunohistochemistry /IHC/ for brown fat marker UCP1, CYP19 (aromatase) and macrophage infiltration markers (CD68, CD163, crown-like structures/CLS) expression.

Plasma exosomal miR-21 and miR-181a differentiates follicular from papillary thyroid cancer.

Thyroid cancer (TC) is the most common endocrine malignancy and its incidence has increased over the last few decades. As has been revealed by a number of studies, TC tissue's micro-RNA (miRNA) profile may reflect histological features and the clinical behavior of tumor. However, alteration of the miRNA profile of plasma exosomes associated with TC development has to date not been explored.

New Insights Into the Role of Imidazolium-Based Promoters for the Electroreduction of CO2 on a Silver Electrode.

The electrochemical reduction of CO2 to CO is a reaction of central importance for sustainable energy conversion and storage. Herein, structure-activity relationships of a series of imidazolium-based cocatalysts for this reaction are described, which demonstrate that the C4- and C5-protons on the imidazolium ring are vital for efficient catalysis. Further investigation of these findings led to the discovery of new imidazolium salts, which show superior activity as cocatalysts for the reaction, i.

Potential and real 'antineoplastic' and metabolic effect of metformin in diabetic and nondiabetic postmenopausal females.

Aim: The goal of this study was to determine if the single nucleotide polymorphisms marking potential sensitivity to metformin (MF) correlate with hormone-metabolic status as well as with actual response to MF in postmenopausal cancer patients with or without Type 2 diabetes mellitus and in diabetics without cancer.

Patients & Methods: The carriage of ten different SNPs was evaluated in all patients by PCR, and hormone-metabolic status was estimated by anthropometry, ELISA and enzyme colorimetric assays. The response to daily 1-1.

An algorithm for score aggregation over causal biological networks based on random walk sampling.

Background: We recently published in BMC Systems Biology an approach for calculating the perturbation amplitudes of causal network models by integrating gene differential expression data. This approach relies on the process of score aggregation, which combines the perturbations at the level of the individual network nodes into a global measure that quantifies the perturbation of the network as a whole. Such "bottom-up" aggregation relates the changes in molecular entities measured by omics technologies to systems-level phenotypes.