Publications by authors named "Dmitry V Sergeev"
The difficulties of behavioral evaluation of prolonged disorders of consciousness (DOC) motivate the development of brain-based diagnostic approaches. The perturbational complexity index (PCI), which measures the complexity of electroencephalographic (EEG) responses to transcranial magnetic stimulation (TMS), showed a remarkable sensitivity in detecting minimal signs of consciousness in previous studies. Here, we tested the reliability of PCI in an independently collected sample of 24 severely brain-injured patients, including 11 unresponsive wakefulness syndrome (UWS), 12 minimally conscious state (MCS) patients, and 1 emergence from MCS patient.
View Article and Find Full Text PDFDiagnostic accuracy of different chronic disorders of consciousness (DOC) can be affected by the false negative errors in up to 40% cases. In the present study, we aimed to investigate the feasibility of a non-Gaussian diffusion approach in chronic DOC and to estimate a sensitivity of diffusion kurtosis imaging (DKI) metrics for the differentiation of vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimally conscious state (MCS) from a healthy brain state. We acquired diffusion MRI data from 18 patients in chronic DOC (11 VS/UWS, 7 MCS) and 14 healthy controls.
View Article and Find Full Text PDFIntroduction: The aim of the study was to develop and validate a Russian adaptation of the Coma Recovery Scale-Revised (CRS-R).
Subjects And Methods: We evaluated 58 patients with chronic disorders of consciousness (> 4 weeks post-injury, DOC) of various etiology and two patients in a locked-in state at different stages after coma. We tested sensitivity for changes over 1 week, reliability, criterion validity and diagnostic sensitivity of the Russian adaptation of the CRS-R in comparison with the Russian adaptations of Full Outline of UnResponsiveness Score (FOUR), and Glasgow Coma Scale (GCS).
Article Synopsis
- The study investigated the effects of birch bark extract (BBE) on patients with chronic hepatitis C (CHC) over a 12-week treatment period.
- Patients experienced significant reductions in liver enzyme levels (ALT and HCV RNA) and improvements in subjective symptoms like fatigue and abdominal discomfort.
- However, the study's limitations, such as the absence of a control group, suggest that further controlled clinical trials are needed to establish the clinical relevance of these findings.