Publications by authors named "Dmitry P Zimin"
A Ni-catalyzed reductive carboxylation of substituted aziridines with CO at atmospheric pressure is disclosed. The protocol is characterized by its mild conditions, experimental ease, and exquisite chemo- and regioselectivity pattern, thus unlocking a new catalytic blueprint to access β-amino acids, important building blocks with considerable potential as peptidomimetics.
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- The study focuses on a gold(I)-catalyzed oxidative annulation process that utilizes ynamides, nitriles, and 2,3-dichloropyridine-oxide as an oxygen atom transfer reagent, changing the outcome to form -1,3-oxazoles instead of aminooxazoles.
- This new method enables the synthesis of 1,3-oxazoles with various sulfonyl-protected alkylamino groups, achieving yields up to 88% across 29 different examples.
- Additionally, using -substituted nitriles, like cyanamides, facilitates the production of challenging-to-synthesize 2,5-diaminooxazoles, and the process is scalable for larger
Facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides RCONHNH (R = Alk or Ar; including those with an additional nucleophilic moiety) in the presence of PhPAuNTf (6 mol %) leading to a wide range of substituted keto- N-acylhydrazones (18 examples) in excellent to good yields (99-66%) is reported. This novel metal-catalyzed coupling proceeds under mild conditions (chlorobenzene, 60 °C), exhibits high functional group tolerance, and is insensitive to the electronic and steric effects of the substituents in the reactants.
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