Publications by authors named "Dmitry M Los'"
Article Synopsis
- This study examines how various immune cells in the rectal cancer microenvironment affect long-term survival, focusing on the roles of tumor-infiltrating T-lymphocytes (TIL-T), B-lymphocytes (TIL-B), IgA plasma cells (IgA PC), and tumor-associated macrophages (TAM).
- Using immunohistochemical staining techniques, researchers analyzed the presence of these immune cells in rectal cancer patients and their connection to outcomes after 5 years post-surgery.
- Key findings indicate that higher levels of TIL-T, TIL-B, and IgA PC are associated with better survival rates, highlighting the potential for using these immune cells in cancer immunotherapy strategies.
Background: New treatment options for metastasised high-grade serous carcinoma (HGSC) are urgently needed. HGSC frequently metastasises to the omentum, inducing angiogenesis in the local omental microvasculature to facilitate tumour growth. We previously showed that HGSC-secreted cathepsin L (CathL) induces pro-angiogenic changes in disease relevant human omental microvascular endothelial cells (HOMECs), suggesting a role in tumour angiogenesis.
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