Cell-Based Modeling of Tissue Developing in the Scaffold Pores of Varying Cross-Sections.

In this work, we present a mathematical model of cell growth in the pores of a perfusion bioreactor through which a nutrient solution is pumped. We have developed a 2-D vertex model that allows us to reproduce the microscopic dynamics of the microenvironment of cells and describe the occupation of the pore space with cells. In this model, each cell is represented by a polygon; the number of vertices and shapes may change over time.

Nonlinear development of convective patterns driven by a neutralization reaction in immiscible two-layer systems.

This article provides the results of a theoretical and experimental study of buoyancy-driven instabilities triggered by a neutralization reaction in an immiscible two-layer system placed in a vertical Hele-Shaw cell. Flow patterns are predicted by a reaction-induced buoyancy number [Formula: see text], which we define as the ratio of densities of the reaction zone and the lower layer. In experiments, we observed the development of cellular convection ([Formula: see text]), the fingering process with an aligned line of fingertips at a slightly denser reaction zone ([Formula: see text]) and the typical Rayleigh-Taylor convection for [Formula: see text].

Biomechanical modeling of invasive breast carcinoma under a dynamic change in cell phenotype: collective migration of large groups of cells.

According to recent studies, cancer is an evolving complex ecosystem. It means that tumor cells are well differentiated and involved in heterotypic interactions with their microenvironment competing for available resources to proliferate and survive. In this paper, we propose a chemo-mechanical model for the growth of specific subtypes of an invasive breast carcinoma.

Spatial analog of the two-frequency torus breakup in a nonlinear system of reactive miscible fluids.

We present a theoretical study on pattern formation occurring in miscible fluids reacting by a second-order reaction A+B→C in a vertical Hele-Shaw cell under constant gravity. We have recently reported that the concentration-dependent diffusion of species coupled with a frontal neutralization reaction can produce a multilayer system where low-density depleted zones could be embedded between the denser layers. This leads to the excitation of chemoconvective modes spatially separated from each other by a motionless fluid.

Shock-wave-like structures induced by an exothermic neutralization reaction in miscible fluids.

We report shock-wave-like structures that are strikingly different from previously observed fingering instabilities, which occur in a two-layer system of miscible fluids reacting by a second-order reaction A+B→S in a vertical Hele-Shaw cell. While the traditional analysis expects the occurrence of a diffusion-controlled convection, we show both experimentally and theoretically that the exothermic neutralization reaction can also trigger a wave with a perfectly planar front and nearly discontinuous change in density across the front. This wave propagates fast compared with the characteristic diffusion times and separates the motionless fluid and the area with anomalously intense convective mixing.

On the extent of surface stagnation produced jointly by insoluble surfactant and thermocapillary flow.

We consider the effect of a partially contaminated interface on the steady thermocapillary flow developed in a two-dimensional slot of finite extent. The contamination is due to the presence of an insoluble surfactant which is carried away by the flow and forms a region of stagnant surface. This problem, first studied in the classical theoretical paper by Carpenter and Homsy (1985, J.

Concentration-dependent diffusion instability in reactive miscible fluids.

We report on chemoconvective pattern formation phenomena observed in a two-layer system of miscible fluids filling a vertical Hele-Shaw cell. We show both experimentally and theoretically that the concentration-dependent diffusion coupled with frontal acid-base neutralization can give rise to the formation of a local unstable zone low in density, resulting in a perfectly regular cell-type convective pattern. The described effect gives an example of yet another powerful mechanism which allows the reaction-diffusion processes to govern the flow of reacting fluids under gravity conditions.