Publications by authors named "Dmitry A Zhaglin"
Novel Antioxidant, Deethylated Ethoxyquin, Protects against Carbon Tetrachloride Induced Hepatotoxicity in Rats by Inhibiting NLRP3 Inflammasome Activation and Apoptosis.
Igor Y Iskusnykh Evgenii D Kryl'skii Darya A Brazhnikova Tatyana N Popova Khidmet S Shikhaliev Dmitry A Zhaglin
Antioxidants (Basel)
January 2021
Article Synopsis
- Inflammation and oxidative stress contribute to acute liver injury (ALI), where the study investigates the effects of deethylated ethoxyquin (DEQ) on this condition in a rat model.
- DEQ treatment improved liver function, reduced harmful gene expression and enzyme activity, inhibited cell death, and lowered pro-inflammatory cytokines.
- The findings suggest DEQ may protect the liver through regulating redox balance and inhibiting the NLRP3 inflammasome, indicating potential for future clinical application.