Publications by authors named "Dmitry A Fedotov"
Article Synopsis
- Pregnancy loss is frequently linked to chromosomal abnormalities, with a study revealing that about 50.4% of spontaneous losses had karyotypically abnormal products of conception, influenced by parental age.
- The researchers examined 94 cases of loss with normal karyotypes and discovered that 35.1% exhibited previously undetected chromosomal issues, raising the overall rate of abnormalities to 67.8%.
- Findings indicate that unlike viable pregnancies, where abnormalities are often limited to chorionic villi, pregnancy losses show more mosaicism in extra-embryonic tissues, highlighting the need for deeper analysis of genomic abnormalities to enhance understanding and treatment.
Ring chromosome 8 (r(8)) is one of the least frequent ring chromosomes. Usually, maternal chromosome 8 forms a ring, which can be lost from cells due to mitotic instability. The 8q24 region contains the imprinted gene, which is expressed from the maternal allele.
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