Publications by authors named "Dmitriy S Fadeev"
Article Synopsis
- The search for new inhibitors of DNA repair enzymes, particularly Tyrosyl-DNA phosphodiesterase 1 (Tdp1), is crucial for improving treatments for cancer and neurodegenerative diseases.
- A new class of semisynthetic small molecule inhibitors derived from bile acids was identified through virtual screening, showing promise to enhance the effectiveness of existing anticancer drugs by reducing Tdp1 activity.
- In vitro studies revealed that these derivatives can inhibit Tdp1 with a potency of up to 0.29 µM, and further docking studies indicate a strong fit of these ligands within Tdp1's active site.
