Multigenic family 110 (1 L-5-6 L) of African swine fever virus modulate cytokine genes expression in vitro.

Background: African swine fever (ASF) is a viral disease that affects pigs and wild boars providing economic burden in swine industry.

Methods And Results: In this study, we investigated the effect of deleting the ASFV multigene family 110 (MGF110) fragment (1 L-5-6 L) on apoptosis modulation and the expression of proinflammatory cytokines. Gene expression in swine peripheral blood macrophages infected with either the parental "Volgograd/14c" strain or the gene-deleted "Volgograd/D(1L-5-6L) MGF110" strain was analyzed.

Administration Routes and Doses of the Attenuated African Swine Fever Virus Strain PSA-1NH Influence Cross-Protection of Pigs against Heterologous Challenge.

African swine fever (ASF) is a lethal hemorrhagic disease of , i.e., domestic pigs and wild boars, caused by African swine fever virus (ASFV).