Publications by authors named "Dmitrii S Bug"
Article Synopsis
- A pilot clinical study showed that oral microbiota transplantation from a healthy mother to her 6-month-old child with neuroblastoma can safely prevent chemotherapy-induced oral mucositis.
- The patient received oral donor saliva during chemotherapy cycles, which led to a significant reduction in the severity of oral mucositis, only experiencing mild symptoms after hematopoietic cell transplantation.
- The study also revealed changes in the patient's oral bacteria, with an increase in beneficial bacteria and a decrease in harmful strains, and no adverse effects from the transplantation were reported.
Article Synopsis
- - Bacteria utilize complex signal transduction systems to adapt to environmental changes, primarily through dedicated ligand binding domains (LBDs) that respond to various signals, including antagonists that inhibit responses. - The study focuses on the LysR-type transcriptional regulator AdmX in Serratia plymuthica, which recognizes the auxin phytohormone indole-3-acetic acid (IAA) and its intermediate, with only IAA regulating antibiotic production. - High-resolution structures reveal that IAA and its antagonist IPA compete for binding to AdmX, and molecular dynamics show significant differences in how they interact; these findings help identify key residues for auxin binding and illustrate the challenges in understanding how antagonists inhibit bacterial signaling.
Myelodysplastic syndrome (MDS) refers to a heterogeneous group of closely related clonal hematopoietic disorders, which are characterized by accumulation of somatic mutations. The acquired mutation burden is suggested to define the pathway and consequent phenotype of the pathology. Recent studies have called attention to the role of miRNA biogenesis genes in MDS progression; in particular, the mutational pressure of the gene was determined.
View Article and Find Full Text PDFUntranslated gene regions (UTRs) play an important role in controlling gene expression. 3'-UTRs are primarily targeted by microRNA (miRNA) molecules that form complex gene regulatory networks. Cancer genomes are replete with non-coding mutations, many of which are connected to changes in tumor gene expression that accompany the development of cancer and are associated with resistance to therapy.
View Article and Find Full Text PDFA number of sequencing studies identified the prognostic impact of somatic mutations in myelodysplastic syndrome (MDS). However the majority of them focused on methylation regulation, apoptosis and proliferation genes. Despite the number of experimental studies published on the role of micro-RNA processing and checkpoint genes in the development of MDS, the clinical data about mutational landscape in these genes is limited.
View Article and Find Full Text PDFOsteopetrosis is a group of rare inheritable disorders of the skeleton characterized by increased bone density. The disease is remarkably heterogeneous in clinical presentation and often misdiagnosed. Therefore, genetic testing and molecular pathogenicity analysis are essential for precise diagnosis and new targets for preventive pharmacotherapy.
View Article and Find Full Text PDF